Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMRJLAT)

Drug Name
Osimertinib Drug Info
Synonyms Tagrisso
Cross-matching ID
PubChem CID
71496458
ChEBI ID
CHEMBL90943
CAS Number
CAS 1421373-65-0
TTD Drug ID
D0O8GK
VARIDT Drug ID
DR00655
ACDINA Drug ID
D00495

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.65 0.00e+0 19/20 (95%) MSMO1;SQLE;DHCR24;...
Lysosome 2.09 0.00e+0 115/128 (89.84%) CTSK;NEU1;ACP5;...
PPAR signaling pathway 2.00 8.30e-3 66/74 (89.19%) HMGCS1;SCD;FABP4;...
Terpenoid backbone biosynthesis 1.97 6.23e-3 18/22 (81.82%) HMGCS1;IDI1;ACAT2;...
Biosynthesis of unsaturated fatty acids 1.95 1.49e-2 21/27 (77.78%) SCD;FADS2;FADS1;...
Kaposi sarcoma-associated herpesvirus infection 1.93 1.66e-2 172/193 (89.12%) CLEC2B;GNG11;MAPK13;...
Synaptic vesicle cycle 1.89 1.78e-2 63/78 (80.77%) STXBP1;ATP6V0B;STX3;...
mTOR signaling pathway 1.82 2.49e-2 114/154 (74.03%) RRAGD;MAP2K1;CAB39;...
Hepatitis C 1.79 3.18e-2 139/157 (88.54%) LDLR;IFIT1;CDKN1A;...
RIG-I-like receptor signaling pathway 1.78 3.24e-2 64/70 (91.43%) MAPK13;DDX3X;ISG15;...
Toll-like receptor signaling pathway 1.74 3.96e-2 94/104 (90.38%) CTSK;LY96;MAPK13;...
Glycolysis / Gluconeogenesis 1.73 3.94e-2 56/67 (83.58%) ALDOC;ADH5;ENO2;...
Measles 1.71 4.12e-2 133/139 (95.68%) TNFAIP3;HSPA6;NFKBIA;...
Epithelial cell signaling in Helicobacter pylori infect... 1.70 4.71e-2 62/70 (88.57%) MAPK13;ATP6V0B;LYN;...
Glycosaminoglycan degradation 1.69 4.65e-2 19/19 (100%) IDS;HGSNAT;HEXB;...
Phagosome 1.68 4.51e-2 118/152 (77.63%) THBS1;THBS2;ATP6V0B;...
Autophagy 1.68 4.47e-2 113/169 (66.86%) SQSTM1;RRAGD;IRS2;...
Systemic lupus erythematosus -1.66 4.01e-2 45/135 (33.33%) ACTN4;HLA-DPA1;ACTN1;...
Base excision repair -1.68 3.78e-2 29/33 (87.88%) POLD1;APEX1;LIG3;...
RNA polymerase -1.69 3.86e-2 23/31 (74.19%) POLR3C;POLR3F;POLR2E;...
Pentose and glucuronate interconversions -1.69 3.72e-2 17/34 (50%) UGP2;UGDH;AKR1B1;...
Ribosome -1.71 3.55e-2 113/158 (71.52%) RPS6;RPS3A;RPS27;...
Mineral absorption -1.73 3.02e-2 48/60 (80%) SLC5A1;STEAP1;MT2A;...
Homologous recombination -1.81 1.21e-2 35/41 (85.37%) BRCA1;POLD1;BABAM2;...
Fanconi anemia pathway -1.84 8.74e-3 36/54 (66.67%) BRCA1;FANCL;FAAP100;...
Arginine and proline metabolism -1.85 3.64e-3 39/50 (78%) ARG1;PYCR3;CNDP2;...
Cell cycle -1.85 4.86e-3 110/124 (88.71%) E2F1;TFDP2;ANAPC13;...
Mismatch repair -1.99 0.00e+0 22/23 (95.65%) RFC4;RFC5;MSH3;...
DNA replication -2.11 0.00e+0 34/36 (94.44%) POLE;POLA1;RFC4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Brain
Glioblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
LN-229 CVCL_0393 Homo sapiens 0.01uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 20uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-474 CVCL_0179 Homo sapiens 0.01uM - 10uM 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CW-2 CVCL_1155 Homo sapiens 0.01uM - 10uM 24H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
SNU-1040 CVCL_5001 Homo sapiens 0.01uM - 10uM 24H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUES 3 CVCL_B062 Homo sapiens 0.04uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AN3 CA CVCL_0146 Homo sapiens 0.01uM - 10uM 24H
MFE-319 CVCL_1409 Homo sapiens 0.01uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 20uM 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
DV-90 CVCL_1184 Homo sapiens 0.01uM - 10uM 24H
NCI-H1563 CVCL_1478 Homo sapiens 0.01uM - 10uM 24H
NCI-H1781 CVCL_1499 Homo sapiens 0.01uM - 10uM 24H
HCC827 CVCL_2063 Homo sapiens 0.01uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H2110 CVCL_1529 Homo sapiens 0.01uM - 10uM 24H
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OC 314 CVCL_1614 Homo sapiens 0.01uM - 10uM 24H
OVCAR-8 CVCL_1625 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
Unclear
Rat sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
XC CVCL_1891 Rattus norvegicus (Rat) 0.01uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
5637 CVCL_0126 Homo sapiens 0.01uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
J82 CVCL_0359 Homo sapiens 0.01uM - 10uM 24H
VM-CUB-1 CVCL_1786 Homo sapiens 0.01uM - 10uM 24H