Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMRKE6W)

Drug Name
VU0255035 Drug Info
Synonyms
1135243-19-4; VU 0255035; N-(3-Oxo-3-(4-(pyridin-4-yl)piperazin-1-yl)propyl)benzo[c][1,2,5]thiadiazole-4-sulfonamide; VU0255035; CHEMBL1628667; N-[3-Oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide; SCHEMBL2730708; GTPL3274; CHEBI:93015; MolPort-023-276-911; BDBM50362367; ZINC43207362; AKOS024457774; AK163845; AX8294949; ST24048355; J-002979; BRD-K58033748-001-01-2
Cross-matching ID
PubChem CID
24768606
ChEBI ID
CHEMBL1628667
TTD Drug ID
D02UNX

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Proteasome 2.33 0.00e+0 44/46 (95.65%) PSMC3;PSMD2;PSMA6;...
DNA replication 2.25 0.00e+0 34/36 (94.44%) RPA3;PRIM1;POLE;...
Ribosome biogenesis in eukaryotes 1.90 2.91e-3 52/108 (48.15%) HEATR1;REXO5;IMP4;...
Spliceosome 1.82 1.53e-2 101/150 (67.33%) HSPA8;SNRPB;SRSF1;...
Cell cycle 1.80 1.22e-2 110/124 (88.71%) CHEK1;CDC20;CCNE2;...
RNA transport 1.76 1.75e-2 128/186 (68.82%) SUMO3;EIF5;CYFIP1;...
Protein digestion and absorption -1.74 4.73e-2 78/103 (75.73%) ATP1A2;COL5A1;COL7A1;...
TNF signaling pathway -1.82 2.62e-2 103/112 (91.96%) CASP7;FOS;BIRC2;...
Rheumatoid arthritis -1.82 3.00e-2 78/93 (83.87%) ATP6V1C1;VEGFA;ATP6V1D;...
Melanoma -1.82 4.00e-2 68/72 (94.44%) FGF7;PIK3CD;PIK3R1;...
AGE-RAGE signaling pathway in diabetic complications -1.87 2.18e-2 97/100 (97%) PIK3CD;PLCE1;PIK3R1;...
Mineral absorption -2.06 1.09e-2 48/60 (80%) MT2A;ATP1A2;CYBRD1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H