Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMRM0OW)

• Drug Name: DADLE Drug Info
• Synonyms: Dadle; 63631-40-3; H-TYR-D-ALA-GLY-PHE-D-LEU-OH; DADL; (D-Ala2,D-Leu5)-Enkephalin; [D-Ala2, D-Leu5]-enkephalin; CHEMBL340032; BW-180C; Tyr-D-Ala-Gly-Phe-D-Leu; (2R,5S,11R,14S)-14-Amino-5-benzyl-15-(4-hydroxyphenyl)-2-isobutyl-11-methyl-4,7,10,13-tetraoxo-3,6,9,12-tetraazapentadecan-1-oic acid; (2R)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid; UNII-HB4QD9GL6F; HB4QD9GL6F; DADLE-OH; AC1OCEJN; ZINC14952092; H-Tyr-D-Ala-Gly-Phe-D-Leu
• Cross-matching ID:
  PubChem CID: 6917707
  ChEBI ID: CHEMBL340032
  CAS Number: CAS 63631-40-3
  TTD Drug ID: D06YMS
  VARIDT Drug ID: DR01490

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Malaria	2.00	0.00e+0	44/50 (88%)	CD40;THBS1;ACKR1;...
TGF-beta signaling pathway	1.99	0.00e+0	81/94 (86.17%)	THBS1;GREM1;RBX1;...
Allograft rejection	1.99	0.00e+0	32/38 (84.21%)	CD40;HLA-DPA1;HLA-DRA;...
Metabolism of xenobiotics by cytochrome P450	1.87	2.26e-2	49/77 (63.64%)	GSTO1;ADH1B;ADH1C;...
Graft-versus-host disease	1.84	2.21e-2	32/42 (76.19%)	HLA-DPA1;HLA-DRA;HLA-DRB1;...
Oxidative phosphorylation	1.83	2.01e-2	93/133 (69.92%)	ATP5F1C;NDUFA4;NDUFB1;...
Drug metabolism	1.75	3.30e-2	78/151 (51.66%)	GSTO1;ADH1B;NAT1;...
Asthma	1.65	4.83e-2	25/31 (80.65%)	CD40;HLA-DPA1;HLA-DRA;...
Type I diabetes mellitus	1.65	4.52e-2	38/43 (88.37%)	HLA-DPA1;HLA-DRA;HLA-DRB1;...
Parkinson disease	1.63	4.86e-2	176/249 (70.68%)	GNAS;PSMA6;ATP5F1C;...
Mineral absorption	1.63	4.52e-2	48/60 (80%)	ATP2B1;ATP1A2;MT1E;...
Basal transcription factors	1.63	4.41e-2	37/45 (82.22%)	GTF2B;MNAT1;GTF2H5;...
Nucleotide excision repair	1.62	4.52e-2	40/47 (85.11%)	RPA3;PCNA;RBX1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Hide ▲