Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMRMFP4)

Drug Name
Inamrinone Lactate Drug Info
Synonyms
Amrinone; inamrinone; 60719-84-8; Wincoram; Inocor; Cordemcura; Cartonic; 5-Amino-[3,4'-bipyridin]-6(1H)-one; Amrinonum [INN-Latin]; Amrinonum; Amrinona; Amrinona [INN-Spanish]; 3-Amino-5-(4-pyridinyl)-2(1H)-pyridinone; Win-40680; Amcoral; 5-Amino-(3,4'-bipyridin)-6(1H)-one; WIN 40680; AWD 08-250; 3-amino-5-pyridin-4-yl-1H-pyridin-2-one; UNII-JUT23379TN; CCRIS 3794; Amrinone lactate; MLS000069829; EINECS 262-390-0; 5-amino-3,4'-bipyridin-6(1H)-one; BRN 0744819; 5-Amino(3,4'-bipyridin)-6(1H)-one; SMR000058850; CHEMBL12856; JUT23379TN; Amrinone Lactate
Therapeutic ClassCardiovascular Agents
Cross-matching ID
PubChem CID
3035194
CAS Number
CAS 75898-90-7
TTD Drug ID
D0R6TI

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
IL-17 signaling pathway 2.17 0.00e+0 84/94 (89.36%) CXCL1;CXCL2;S100A7;...
Oxidative phosphorylation 2.01 0.00e+0 93/133 (69.92%) NDUFB5;NDUFA6;ATP5MC3;...
Ribosome 1.97 0.00e+0 113/158 (71.52%) MRPS16;RPL26L1;RPS4Y1;...
Type I diabetes mellitus 1.97 0.00e+0 38/43 (88.37%) PTPRN2;CPE;CD86;...
Legionellosis 1.97 0.00e+0 51/57 (89.47%) CXCL1;CXCL2;CXCL8;...
Allograft rejection 1.95 1.45e-3 32/38 (84.21%) CD86;HLA-F;HLA-B;...
Graft-versus-host disease 1.92 1.25e-3 32/42 (76.19%) CD86;IL6;HLA-F;...
Proteasome 1.89 4.36e-3 44/46 (95.65%) PSMB8;PSMB9;PSMB7;...
Autoimmune thyroid disease 1.85 8.72e-3 46/53 (86.79%) CD86;HLA-F;HLA-B;...
Epithelial cell signaling in Helicobacter pylori infect... 1.85 8.72e-3 62/70 (88.57%) CXCL1;LYN;CXCL2;...
Parkinson disease 1.83 1.03e-2 176/249 (70.68%) NDUFB5;PPIF;NDUFA6;...
Rheumatoid arthritis 1.78 1.45e-2 78/93 (83.87%) CXCL1;CXCL2;CXCL8;...
NOD-like receptor signaling pathway 1.74 1.68e-2 145/181 (80.11%) CXCL1;CXCL2;CXCL8;...
Huntington disease 1.70 2.55e-2 233/306 (76.14%) NDUFB5;GRIA2;GPX1;...
Primary bile acid biosynthesis 1.70 2.62e-2 15/17 (88.24%) AMACR;ACOX2;CYP27A1;...
Histidine metabolism 1.69 2.83e-2 16/22 (72.73%) ALDH3A1;HNMT;ALDH2;...
Thyroid hormone signaling pathway -1.70 4.89e-2 112/121 (92.56%) PLCD1;HRAS;MAPK1;...
Proteoglycans in cancer -1.70 4.63e-2 172/205 (83.9%) TWIST1;ITPR3;IGF1R;...
Arrhythmogenic right ventricular cardiomyopathy -1.72 4.14e-2 70/77 (90.91%) ITGA4;ITGA5;SGCD;...
Glycerophospholipid metabolism -1.72 4.63e-2 71/98 (72.45%) PLA2G15;ETNK1;CHKB;...
Estrogen signaling pathway -1.76 4.63e-2 119/137 (86.86%) ADCY7;PGR;ITPR3;...
Insulin signaling pathway -1.82 3.09e-2 121/137 (88.32%) IRS2;RPS6KB1;PRKAA1;...
Lysosome -1.83 4.63e-2 115/128 (89.84%) CTNS;MANBA;PPT2;...
Bacterial invasion of epithelial cells -1.93 2.32e-2 59/77 (76.62%) ITGA5;ELMO1;ILK;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 24H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H