Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMRNGD2)

Drug Name
Daprodustat Drug Info
Synonyms
GSK1278863; Daprodustat; 960539-70-2; GSK1278863; UNII-JVR38ZM64B; GSK-1278863; JVR38ZM64B; N-((1,3-Dicyclohexylhexahydro-2,4,6-trioxopyrimidin-5-yl)carbonyl)glycine; Daprodustat [USAN:INN]; GSK 1278863; Daprodustat(GSK1278863); Daprodustat; GSK1278863; Daprodustat (JAN/USAN/INN); GTPL8455; Daprodustat (GSK1278863); CHEMBL3544988; KS-00000M8Z; EX-A1121; BCP16766; s8171; AKOS027439964; Glycine, N-((1,3-dicyclohexylhexahydro-2,4,6-trioxo-5-pyrimidinyl)carbonyl)-; ZINC231226004; CS-5453; SB19761; DB11682; HY-17608; J3.560.573H; D10874
Cross-matching ID
PubChem CID
91617630
ChEBI ID
CHEMBL3544988
CAS Number
CAS 960539-70-2
TTD Drug ID
D0F6JC
INTEDE Drug ID
DR1824

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
HIF-1 signaling pathway 2.47 0.00e+0 105/109 (96.33%) ALDOC;ENO2;HK2;...
Glycolysis / Gluconeogenesis 2.46 0.00e+0 56/67 (83.58%) ALDOC;ENO2;HK2;...
Fructose and mannose metabolism 2.32 3.74e-3 30/33 (90.91%) ALDOC;HK2;PFKFB3;...
Starch and sucrose metabolism 2.20 2.80e-3 25/36 (69.44%) HK2;GPI;GBE1;...
Pentose phosphate pathway 2.13 2.24e-3 25/30 (83.33%) ALDOC;GPI;PFKP;...
Galactose metabolism 1.98 9.34e-3 26/31 (83.87%) HK2;PFKP;PGM1;...
Central carbon metabolism in cancer 1.97 1.28e-2 67/70 (95.71%) HK2;SLC2A1;PGAM1;...
Mitophagy 1.84 3.92e-2 56/68 (82.35%) BNIP3;BNIP3L;BCL2L1;...
Arginine biosynthesis -1.68 4.28e-2 17/22 (77.27%) OTC;ARG2;GLS2;...
Synthesis and degradation of ketone bodies -1.72 3.27e-2 9/10 (90%) ACAT2;OXCT1;BDH1;...
Alanine, aspartate and glutamate metabolism -1.76 1.68e-2 27/37 (72.97%) GFPT2;CPS1;ADSL;...
Cysteine and methionine metabolism -1.79 1.56e-2 43/50 (86%) GCLC;MDH1;AHCYL1;...
RNA transport -1.81 1.40e-2 128/186 (68.82%) NUP160;SUMO1;EIF2S1;...
Proteasome -1.91 3.36e-3 44/46 (95.65%) PSMF1;PSME1;PSMA3;...
Complement and coagulation cascades -1.94 0.00e+0 76/85 (89.41%) KLKB1;MBL2;CR1;...
Citrate cycle (TCA cycle) -2.03 0.00e+0 30/30 (100%) MDH1;SDHA;IDH3A;...
Ribosome biogenesis in eukaryotes -2.09 0.00e+0 52/108 (48.15%) RBM28;PWP2;EFL1;...
Systemic lupus erythematosus -2.10 0.00e+0 45/135 (33.33%) SNRPB;C9;C2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H