Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMROWV8)

Drug Name
ZK-164015 Drug Info
Synonyms
ZK 164015; 177583-70-9; ZK-164015; 2-(4-HYDROXYPHENYL)-3-METHYL-1-[10-(PENTYLSULFONYL)DECYL]-1H-INDOL-5-OL; CHEMBL184074; SCHEMBL7133598; CHEBI:92087; CTK4D6535; DTXSID00430964; MolPort-006-822-606; HMS3268P09; ZINC8022535; AKOS024456974; NCGC00092322-01; RT-016336; B6960; J-011295; BRD-K05151076-001-01-8
Cross-matching ID
PubChem CID
9806489
ChEBI ID
CHEMBL184074
CAS Number
CAS 177583-70-9
TTD Drug ID
D0P0FN

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
TNF signaling pathway 2.10 0.00e+0 103/112 (91.96%) CXCL3;CXCL1;JAG1;...
NF-kappa B signaling pathway 1.95 9.00e-3 90/104 (86.54%) CXCL3;BCL2A1;CXCL8;...
IL-17 signaling pathway 1.94 6.00e-3 84/94 (89.36%) CXCL3;CXCL8;CXCL1;...
Viral protein interaction with cytokine and cytokine re... 1.88 1.12e-2 84/100 (84%) CXCL3;CXCL8;ACKR3;...
Rheumatoid arthritis 1.78 3.24e-2 78/93 (83.87%) CXCL3;CXCL8;CXCL1;...
Fluid shear stress and atherosclerosis 1.76 4.50e-2 123/139 (88.49%) HMOX1;ARHGEF2;THBD;...
Thermogenesis -1.76 3.01e-2 173/232 (74.57%) GRB2;COX8A;NDUFS7;...
Progesterone-mediated oocyte maturation -1.78 2.49e-2 75/100 (75%) CDC27;CDC25C;MAP2K1;...
Cell cycle -1.80 2.54e-2 110/124 (88.71%) RBL1;ORC1;MCM3;...
Drug metabolism -1.82 2.64e-2 78/151 (51.66%) CDA;CES1;ADH1A;...
Oxidative phosphorylation -1.89 1.70e-2 93/133 (69.92%) COX8A;NDUFS7;NDUFS3;...
DNA replication -1.90 3.39e-2 34/36 (94.44%) PRIM1;MCM3;POLD1;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H