Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMRSATG)

• Drug Name: Abamectin B1A Drug Info
• Synonyms: AVERMECTIN B1A; abamectin component B1a; Avermectin B(1)a; Abamectine [French]; Abamectinum [Latin]; Abamectina [Spanish]; Caswell No. 063AB; Antibiotic C 076B1a; Abamectin komponente B1a; 5-O-Demethylavermectin A1a; UNII-K54ZMM929K; Avermectin; Avermectin A1a, 5-O-demethyl-; EINECS 265-610-3; Antibiotic C 076A1a, 5-O-demethyl-; K54ZMM929K; CHEBI:29534; Avermectin A(sub 1a), 5-O-demethyl-; DSSTox_CID_3892; DSSTox_RID_77221; DSSTox_GSID_23892; Abamectina; Abamectine; C48H72O14; Abamectin B1a
• Cross-matching ID:
  PubChem CID: 6434889
  ChEBI ID: CHEMBL1630577
  CAS Number: CAS 65195-55-3
  VARIDT Drug ID: DR01583

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Mismatch repair	-1.76	4.98e-2	22/23 (95.65%)	MSH2;RFC3;POLD1;...
Diabetic cardiomyopathy	-1.84	3.77e-2	162/203 (79.8%)	AGT;SP1;NDUFS2;...
Citrate cycle (TCA cycle)	-1.91	1.70e-2	30/30 (100%)	CS;ACO1;MDH1;...
DNA replication	-2.19	0.00e+0	34/36 (94.44%)	RNASEH2B;RFC3;MCM4;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Hide ▲