Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMRSU4X)

• Drug Name: Salirasib Drug Info
• Synonyms: 162520-00-5; Farnesylthiosalicylic acid; S-Farnesylthiosalicylic acid; UNII-MZH0OM550M; MZH0OM550M; CHEMBL23293; AK186909; Farnesyl Thiosalicylic Acid; 2-[[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl]thio]benzoic Acid; 2-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]sulfanylbenzoic acid; 2-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienylthio)benzoic acid; 2-(((2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrienyl)sulfanyl)benzoic acid; Benzoic acid, 2-(((2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrienyl)thio)-; FTS; Farnesylthiosalicyclic acid; FTS, Thyreos; Ras antagonists, Thyreos; S-trans; Th-101; Trans-farnesylthiosalicylicacid; FTS (oral, cancer), Concordia; Farnesylthiosalicyclic acid (oral, cancer), Concordia; Ras-inhibitors (cancer), Concordia; FTS (oral, cancer), Concordia/Ono; KD032
• Cross-matching ID:
  PubChem CID: 5469318
  ChEBI ID: CHEMBL23293
  CAS Number: CAS 162520-00-5
  TTD Drug ID: D00KTV

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Cell cycle	1.96	0.00e+0	110/124 (88.71%)	CCNB1;MAD2L1;CCNB2;...
DNA replication	1.86	1.63e-2	34/36 (94.44%)	MCM5;MCM6;PCNA;...
Lipid and atherosclerosis	-1.68	4.80e-2	190/215 (88.37%)	TNFRSF10B;HSPA4;TNFRSF1A;...
D-Glutamine and D-glutamate metabolism	-1.69	4.99e-2	5/5 (100%)	GLS2;GLUD2;GLUD1;...
Drug metabolism	-1.71	4.03e-2	78/151 (51.66%)	CES1;CMPK1;FMO1;...
Inflammatory bowel disease	-1.72	4.29e-2	58/65 (89.23%)	SMAD3;IL10;HLA-DOA;...
Bile secretion	-1.72	4.60e-2	68/90 (75.56%)	SCTR;EPHX1;ATP1B3;...
Viral myocarditis	-1.84	1.83e-2	53/60 (88.33%)	HLA-DOA;EIF4G3;HLA-DQA1;...
Viral protein interaction with cytokine and cytokine re...	-1.86	1.33e-2	84/100 (84%)	CCR4;CX3CL1;CCL4;...
Metabolism of xenobiotics by cytochrome P450	-1.87	1.52e-2	49/77 (63.64%)	UGT2B15;ADH1C;GSTP1;...
Allograft rejection	-1.91	1.18e-2	32/38 (84.21%)	IL10;HLA-DOA;HLA-DQA1;...
Retinol metabolism	-1.92	1.42e-2	41/68 (60.29%)	CYP2C18;UGT2B15;RDH16;...
Coronavirus disease	-1.99	5.90e-3	215/232 (92.67%)	CXCL8;RPS9;RPL18;...
Cholesterol metabolism	-2.03	3.93e-3	44/50 (88%)	LIPC;MYLIP;NPC1;...
Staphylococcus aureus infection	-2.04	0.00e+0	72/95 (75.79%)	FPR3;DSG1;FCGR2C;...
Complement and coagulation cascades	-2.12	0.00e+0	76/85 (89.41%)	A2M;C8A;FGB;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 2.22uM	24H	Hide ▲

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 2.22uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 2.22uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 2.22uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 2.22uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 2.22uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼