Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMRVBWU)

Drug Name
Bentazepam Drug Info
Cross-matching ID
PubChem CID
135412795
ChEBI ID
CHEMBL135252
CAS Number
CAS 29462-18-8
TTD Drug ID
D0N8DP

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Amino sugar and nucleotide sugar metabolism -1.62 4.61e-2 38/48 (79.17%) GCK;CHIT1;GNE;...
Phenylalanine metabolism -1.63 4.32e-2 14/17 (82.35%) GLYAT;MAOA;HPD;...
Galactose metabolism -1.65 4.00e-2 26/31 (83.87%) LALBA;GCK;LCT;...
Renin-angiotensin system -1.67 3.54e-2 20/23 (86.96%) AGT;CPA3;ENPEP;...
Neomycin, kanamycin and gentamicin biosynthesis -1.67 3.65e-2 5/5 (100%) GCK;HK1;HK2
Butanoate metabolism -1.71 2.53e-2 23/28 (82.14%) AACS;EHHADH;ACAT1;...
Glycine, serine and threonine metabolism -1.71 2.52e-2 31/40 (77.5%) SHMT1;GAMT;MAOA;...
Histidine metabolism -1.74 2.06e-2 16/22 (72.73%) ALDH3B1;ALDH1B1;HNMT;...
Folate biosynthesis -1.74 2.25e-2 23/26 (88.46%) GGH;GPHN;PAH;...
Glyoxylate and dicarboxylate metabolism -1.75 2.21e-2 23/30 (76.67%) SHMT1;CAT;ACAT1;...
Fructose and mannose metabolism -1.83 5.89e-3 30/33 (90.91%) HK1;ALDOC;PFKM;...
Mismatch repair -1.85 6.63e-3 22/23 (95.65%) POLD2;PCNA;MLH1;...
Pyruvate metabolism -1.87 6.31e-3 41/47 (87.23%) ALDH1B1;FH;ADH7;...
Citrate cycle (TCA cycle) -1.89 7.37e-3 30/30 (100%) IDH3A;ACO2;SUCLG1;...
Nitrogen metabolism -1.96 7.07e-3 16/17 (94.12%) CA5A;GLUD2;GLUD1;...
Glycolysis / Gluconeogenesis -1.99 6.63e-3 56/67 (83.58%) ALDH3A2;ENO3;HK1;...
Glutathione metabolism -2.00 5.89e-3 43/57 (75.44%) GPX7;GSTP1;GSTM4;...
Tryptophan metabolism -2.15 0.00e+0 35/42 (83.33%) EHHADH;DHTKD1;CAT;...
DNA replication -2.30 0.00e+0 34/36 (94.44%) PRIM1;POLA2;DNA2;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H