Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMRVUCY)

Drug Name
S-111 Drug Info
Synonyms PARP1 inhibitor (cancer), Sentinel Oncology
Cross-matching ID
PubChem CID
11213350
TTD Drug ID
D0EQ1J

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.23 0.00e+0 34/36 (94.44%) POLE2;RPA3;PRIM1;...
Base excision repair 1.93 0.00e+0 29/33 (87.88%) POLE2;PCNA;POLD2;...
Cell cycle 1.85 1.44e-2 110/124 (88.71%) CHEK1;CCNE2;PLK1;...
Mismatch repair 1.80 2.60e-2 22/23 (95.65%) RPA3;PCNA;RFC4;...
Axon guidance -1.72 4.43e-2 151/182 (82.97%) CAMK2B;EPHA7;RHOD;...
Ascorbate and aldarate metabolism -1.73 4.53e-2 15/30 (50%) UGT2B4;AKR1A1;KL;...
Sulfur metabolism -1.74 3.77e-2 9/10 (90%) SELENBP1;PAPSS1;PAPSS2;...
Viral protein interaction with cytokine and cytokine re... -1.75 3.57e-2 84/100 (84%) CCR1;CCR9;CCL21;...
Metabolism of xenobiotics by cytochrome P450 -1.76 3.46e-2 49/77 (63.64%) UGT2B4;CYP3A5;CYP2A6;...
Steroid hormone biosynthesis -1.80 2.53e-2 43/61 (70.49%) UGT2B4;CYP3A5;COMT;...
Mineral absorption -1.82 2.40e-2 48/60 (80%) STEAP1;TF;SLC34A2;...
Coronavirus disease -1.82 2.88e-2 215/232 (92.67%) RPS17;RELA;FCGR2A;...
NF-kappa B signaling pathway -1.86 1.39e-2 90/104 (86.54%) CCL21;EDAR;LBP;...
Tryptophan metabolism -1.95 7.39e-3 35/42 (83.33%) ECHS1;EHHADH;DHTKD1;...
Complement and coagulation cascades -2.03 0.00e+0 76/85 (89.41%) ITGAM;C8B;C5AR1;...
Retinol metabolism -2.17 0.00e+0 41/68 (60.29%) UGT2B4;CYP3A5;CYP2A6;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Fibrocystic breast disease
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A (Parent) CVCL_0598 Homo sapiens 1.11uM - 10uM 3H, 6H, 12H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 24H