Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMRW5J4)

Drug Name
Benzyl-quinazolin-4-yl-amine Drug Info
Synonyms
N-Benzylquinazolin-4-amine; N-benzyl-N-(4-quinazolinyl)amine; 4-(Benzylamino)quinazoline; Benzyl-quinazolin-4-yl-amine; 100818-54-0; 4-Benzylaminoquinazoline; AC1LDDI3; benzylquinazolin-4-ylamine; ChemDiv2_003678; N-benzyl-4-quinazolineamine; Oprea1_089836; MLS000701321; N-Benzyl-4-quinazolinamine #; cid_616573; CHEMBL102726; BDBM3256; SCHEMBL7612718; CHEBI:92768; MolPort-001-960-903; FVWANTDQRFSCAL-UHFFFAOYSA-N; HMS2233F15; HMS3373H15; HMS1379H04; ZINC109589; 4-[(phenylmethyl)amino]quinazoline; N-(phenylmethyl)-4-quinazolinamine
Cross-matching ID
PubChem CID
6603129
ChEBI ID
CHEMBL1444764
TTD Drug ID
D01WDI

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Glycine, serine and threonine metabolism 2.29 0.00e+0 31/40 (77.5%) PSAT1;GATM;MAOA;...
Endocrine and other factor-regulated calcium reabsorpti... 2.13 0.00e+0 49/53 (92.45%) PRKACB;ADCY9;PLCB4;...
Citrate cycle (TCA cycle) 2.13 0.00e+0 30/30 (100%) PCK2;PCK1;ACO1;...
Glutamatergic synapse 2.06 0.00e+0 97/114 (85.09%) SLC1A1;SLC38A1;PRKACB;...
Proximal tubule bicarbonate reclamation 2.04 2.30e-3 21/23 (91.3%) PCK2;PCK1;CA2;...
Tryptophan metabolism 2.02 1.91e-3 35/42 (83.33%) AOX1;MAOA;ACAT1;...
Alanine, aspartate and glutamate metabolism 2.02 1.64e-3 27/37 (72.97%) CPS1;ASS1;ASNS;...
Retinol metabolism 1.92 1.15e-2 41/68 (60.29%) AOX1;ALDH1A3;CYP26B1;...
Aldosterone synthesis and secretion 1.90 1.15e-2 85/98 (86.73%) PRKACB;STAR;ADCY9;...
Sulfur metabolism 1.86 1.26e-2 9/10 (90%) PAPSS2;SQOR;ETHE1
Glycolysis / Gluconeogenesis 1.85 1.36e-2 56/67 (83.58%) PCK2;PCK1;PFKP;...
GABAergic synapse 1.85 1.24e-2 76/89 (85.39%) SLC38A1;PRKACB;ADCY9;...
Phenylalanine metabolism 1.84 1.15e-2 14/17 (82.35%) MAOA;GOT1;MAOB;...
Insulin secretion 1.83 1.31e-2 75/86 (87.21%) PRKACB;ADCY9;PLCB4;...
Ether lipid metabolism 1.82 1.22e-2 32/49 (65.31%) PLA2G2A;PLPP1;LPCAT4;...
Pentose phosphate pathway 1.82 1.15e-2 25/30 (83.33%) PFKP;ALDOB;FBP1;...
Cortisol synthesis and secretion 1.82 1.08e-2 58/65 (89.23%) PRKACB;STAR;ADCY9;...
Tyrosine metabolism 1.81 1.21e-2 30/36 (83.33%) AOX1;MAOA;GOT1;...
Glyoxylate and dicarboxylate metabolism 1.80 1.27e-2 23/30 (76.67%) ACAT1;SHMT2;ACO1;...
Dopaminergic synapse 1.79 1.32e-2 115/132 (87.12%) PRKACB;MAOA;PLCB4;...
Metabolism of xenobiotics by cytochrome P450 1.78 1.37e-2 49/77 (63.64%) CYP1A2;GSTT1;HSD11B1;...
Glucagon signaling pathway 1.77 1.46e-2 89/107 (83.18%) PCK2;PCK1;PFKP;...
Cocaine addiction 1.72 2.00e-2 42/49 (85.71%) FOSB;PRKACB;MAOA;...
Amoebiasis 1.72 1.96e-2 99/102 (97.06%) PRKACB;COL4A3;PLCB4;...
Renin secretion 1.71 1.93e-2 61/69 (88.41%) PRKACB;PLCB4;GNAQ;...
One carbon pool by folate 1.70 2.03e-2 15/20 (75%) SHMT2;DHFR;MTHFD1;...
Adrenergic signaling in cardiomyocytes 1.69 2.17e-2 130/150 (86.67%) PRKACB;ADCY9;PLCB4;...
Arginine and proline metabolism 1.69 2.30e-2 39/50 (78%) GATM;MAOA;GOT1;...
Insulin resistance 1.67 2.57e-2 96/108 (88.89%) PCK2;PCK1;PYGB;...
Drug metabolism 1.67 2.56e-2 78/151 (51.66%) AOX1;FMO1;MAOA;...
Circadian rhythm -1.75 4.17e-2 26/31 (83.87%) CREB1;CSNK1E;PER3;...
Basal transcription factors -1.83 2.00e-2 37/45 (82.22%) GTF2H5;TBP;GTF2F1;...
TGF-beta signaling pathway -1.94 8.02e-3 81/94 (86.17%) SMAD2;SMAD1;SMAD5;...
Steroid biosynthesis -2.22 0.00e+0 19/20 (95%) NSDHL;SC5D;FDFT1;...
Spliceosome -2.47 0.00e+0 101/150 (67.33%) THOC1;HSPA1L;SYF2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H