Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMRWLB2)

Drug Name
Fluticasone propionate Drug Info
Synonyms
FLUTICASONE PROPIONATE; Flovent; Cutivate; Flixotide; Flonase; Flixonase; Flovent HFA; Flunase; Flutide; Fluspiral; Flusonal; atemur; Flutivate; Fluinol; Axotide; Asmatil; Brethal; Flovent Diskus 50; Flixotide Disks; Flixotide Disk; Flovent Diskus; Flovent Diskus 100; Flovent Diskus 250; Flixotide Inhaler; Trialona; Rinosone; Inalacor; Cultivate; Ubizol; Zoflut; Flixonase Nasal Spray; Flonase Aq; Fluticasonpropionat Allen; Fluticasone (propionate); UNII-O2GMZ0LF5W; CCI-18781; CCI 18781; MFCD00866007; O2GMZ0LF5W
Cross-matching ID
PubChem CID
444036
ChEBI ID
CHEMBL1473
CAS Number
CAS 80474-14-2
VARIDT Drug ID
DR01643

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.32 0.00e+0 34/36 (94.44%) RFC2;POLE2;MCM4;...
Complement and coagulation cascades 2.27 0.00e+0 76/85 (89.41%) CFD;SERPINE1;C7;...
Tyrosine metabolism 2.01 0.00e+0 30/36 (83.33%) MAOA;AOX1;AOC3;...
Glyoxylate and dicarboxylate metabolism 1.92 1.17e-2 23/30 (76.67%) GLUL;SHMT1;GLDC;...
PPAR signaling pathway 1.89 1.40e-2 66/74 (89.19%) ACSL1;LPL;SORBS1;...
Drug metabolism 1.87 1.55e-2 78/151 (51.66%) MAOA;AOX1;MAOB;...
Phenylalanine metabolism 1.84 2.11e-2 14/17 (82.35%) MAOA;AOC3;MAOB;...
Fatty acid degradation 1.78 3.50e-2 40/43 (93.02%) ACSL1;ADH1B;ALDH3A2;...
Alanine, aspartate and glutamate metabolism 1.75 3.28e-2 27/37 (72.97%) GLUL;ASL;ABAT;...
Vitamin digestion and absorption 1.73 3.81e-2 17/24 (70.83%) SLC19A2;APOB;TCN2;...
One carbon pool by folate 1.73 3.53e-2 15/20 (75%) SHMT1;MTHFD1;ALDH1L1;...
Retinol metabolism 1.71 3.56e-2 41/68 (60.29%) AOX1;ALDH1A1;ADH1B;...
Aminoacyl-tRNA biosynthesis 1.70 3.47e-2 15/66 (22.73%) IARS2;CARS2;QRSL1;...
Vibrio cholerae infection -1.66 4.95e-2 44/50 (88%) SEC61G;ATP6AP1;PLCG2;...
Morphine addiction -1.71 3.17e-2 80/91 (87.91%) GNB5;GABRB1;PDE1C;...
Primary immunodeficiency -1.71 3.14e-2 33/38 (86.84%) CD40LG;CD3D;DCLRE1C;...
Maturity onset diabetes of the young -1.72 3.17e-2 21/26 (80.77%) FOXA2;HHEX;NKX2-2;...
Sphingolipid metabolism -1.72 3.21e-2 32/49 (65.31%) GLB1;PSAP;B4GALT6;...
Leukocyte transendothelial migration -1.78 1.35e-2 90/114 (78.95%) RAPGEF4;RHOA;CTNNA2;...
Riboflavin metabolism -1.79 1.44e-2 7/8 (87.5%) RFK;BLVRB;ENPP1;...
Epithelial cell signaling in Helicobacter pylori infect... -1.79 1.54e-2 62/70 (88.57%) ATP6AP1;ADAM17;PLCG2;...
Allograft rejection -1.82 1.07e-2 32/38 (84.21%) HLA-B;IFNG;HLA-DPB1;...
TNF signaling pathway -1.84 8.46e-3 103/112 (91.96%) TAB2;CSF2;BCL3;...
Cell adhesion molecules -1.86 6.92e-3 118/148 (79.73%) NRXN2;SELPLG;CD22;...
Graft-versus-host disease -1.88 5.07e-3 32/42 (76.19%) KIR3DL1;IL1B;HLA-B;...
Autoimmune thyroid disease -1.89 4.23e-3 46/53 (86.79%) FASLG;CD80;IFNA17;...
Protein processing in endoplasmic reticulum -1.91 3.17e-3 127/171 (74.27%) MAN1A1;NFE2L2;BCL2;...
Asthma -1.94 3.62e-3 25/31 (80.65%) HLA-DPB1;FCER1A;TNF;...
Type I diabetes mellitus -1.96 4.23e-3 38/43 (88.37%) FASLG;CD80;GAD2;...
Viral protein interaction with cytokine and cytokine re... -1.98 5.07e-3 84/100 (84%) IL24;CCL13;CX3CL1;...
Intestinal immune network for IgA production -2.01 6.34e-3 38/48 (79.17%) CCL25;ICOS;CCR10;...
IL-17 signaling pathway -2.02 8.46e-3 84/94 (89.36%) IFNG;MAPK8;CCL17;...
Antigen processing and presentation -2.25 0.00e+0 60/78 (76.92%) HSPA1L;CTSB;HLA-B;...
Rheumatoid arthritis -2.35 0.00e+0 78/93 (83.87%) ATP6V0E2;HLA-DPB1;ATP6V0C;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 4uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H