Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMRWXH4)

Drug Name
Quinoxaline1 Drug Info
Synonyms quinoxaline1
Cross-matching ID
PubChem CID
438981
ChEBI ID
CHEMBL259389
CAS Number
CAS 56984-56-6
TTD Drug ID
D0R5FH

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome 2.01 0.00e+0 113/158 (71.52%) RPS4Y1;MRPS12;MRPL17;...
Folate biosynthesis 1.99 0.00e+0 23/26 (88.46%) AKR1C3;AKR1B1;QDPR;...
Glycolysis / Gluconeogenesis 1.97 0.00e+0 56/67 (83.58%) PGAM1;PKM;GPI;...
DNA replication 1.93 0.00e+0 34/36 (94.44%) PCNA;MCM3;POLE3;...
Ribosome biogenesis in eukaryotes 1.85 8.65e-3 52/108 (48.15%) FBL;IMP3;NOL6;...
Pentose phosphate pathway 1.74 2.88e-2 25/30 (83.33%) TKTL1;GPI;TKT;...
Allograft rejection 1.73 2.96e-2 32/38 (84.21%) HLA-DQA1;HLA-F;CD40;...
Nucleotide excision repair 1.71 3.57e-2 40/47 (85.11%) PCNA;RAD23B;POLE3;...
Asthma 1.70 3.84e-2 25/31 (80.65%) HLA-DQA1;CD40;FCER1A;...
Type I diabetes mellitus 1.69 3.80e-2 38/43 (88.37%) HLA-DQA1;HLA-F;IL1A;...
Fructose and mannose metabolism 1.67 4.17e-2 30/33 (90.91%) AKR1B1;PFKL;TPI1;...
Primary bile acid biosynthesis 1.64 4.97e-2 15/17 (88.24%) AMACR;ACOX2;SLC27A5;...
Steroid biosynthesis -2.15 0.00e+0 19/20 (95%) LBR;SOAT2;DHCR7;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H