Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMRXHAC)

Drug Name
Otenzepad Drug Info
Synonyms
Otenzepad; AF-DX 116; 102394-31-0; AF-DX-116; 11-(2-(2-((Diethylamino)methyl)piperidin-1-yl)acetyl)-5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one; UNII-WW6A9TFL2C; UNII-SX2WTG9R3Z; WW6A9TFL2C; SX2WTG9R3Z; 11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE; BRN 4212983; CHEMBL17045; NSC664529; 100158-38-1; NCGC00025002-02; DSSTox_RID_81048; DSSTox_CID_25674; DSSTox_GSID_45674; 6H-Pyrido(2,3-b)(1,4)benzodiazepin-6-one, 11-((2-((diethylamino)methyl)-1-piperidinyl)acetyl)
Cross-matching ID
PubChem CID
107867
ChEBI ID
CHEMBL17045
CAS Number
CAS 102394-31-0
TTD Drug ID
D0A2OW

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
p53 signaling pathway 1.95 1.44e-2 63/73 (86.3%) SERPINB5;BAX;CDK6;...
Ovarian steroidogenesis -1.70 4.98e-2 41/51 (80.39%) AKR1C3;HSD17B1;ADCY3;...
Other glycan degradation -1.73 3.98e-2 13/18 (72.22%) HEXA;FUCA1;NEU1;...
Type I diabetes mellitus -1.74 4.42e-2 38/43 (88.37%) HLA-G;GAD1;PRF1;...
Phagosome -1.74 4.36e-2 118/152 (77.63%) TUBB1;ATP6V0A1;C3;...
Antigen processing and presentation -1.75 4.27e-2 60/78 (76.92%) HSP90AA1;HSPA6;B2M;...
Rap1 signaling pathway -1.76 3.73e-2 184/210 (87.62%) FGF4;FGF20;CSF1R;...
Dilated cardiomyopathy -1.76 4.48e-2 86/96 (89.58%) TGFB1;ITGB4;SGCA;...
Circadian entrainment -1.77 4.98e-2 85/97 (87.63%) CALML5;CACNA1D;GRIA1;...
Long-term depression -1.81 4.56e-2 55/60 (91.67%) MAPK1;PLA2G4A;PLCB3;...
Platelet activation -1.84 4.98e-2 106/124 (85.48%) FYN;ARHGEF12;ARHGAP35;...
Gap junction -2.07 1.24e-2 72/88 (81.82%) ADCY3;TUBB1;ITPR3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H