Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMRYHWI)

Drug Name
SB-705498 Drug Info
Synonyms
SB-705498; 501951-42-4; SB705498; SB 705498; UNII-T74V9O0Y2W; (R)-1-(2-bromophenyl)-3-(1-(5-(trifluoromethyl)pyridin-2-yl)pyrrolidin-3-yl)urea; T74V9O0Y2W; 1-(2-bromophenyl)-3-[(3R)-1-[5-(trifluoromethyl)pyridin-2-yl]pyrrolidin-3-yl]urea; N-(2-Bromophenyl)-N'-[(3R)-1-[5-(trifluoromethyl)-2-pyridinyl]-3-pyrrolidinyl]urea; 1-(2-Bromophenyl)-3-[(3R)-1-[5-(trifluoromethyl)-2-pyridyl]pyrrolidin-3-yl]urea; JYILLRHXRVTRSH-GFCCVEGCSA-N; MLS006011113; SCHEMBL1350298; GTPL4311; CHEMBL207433; BMCL163287 Compound 15; BDBM20504
Cross-matching ID
PubChem CID
9910486
ChEBI ID
CHEMBL207433
CAS Number
CAS 501951-42-4
TTD Drug ID
D0VJ5N

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Toll-like receptor signaling pathway -1.64 3.90e-2 94/104 (90.38%) CHUK;MAPK11;TLR8;...
Pyruvate metabolism -1.64 4.01e-2 41/47 (87.23%) PDHB;LDHA;LDHAL6B;...
Pentose and glucuronate interconversions -1.73 1.56e-2 17/34 (50%) AKR1A1;RPE;UGT2B4;...
Retinol metabolism -1.73 1.66e-2 41/68 (60.29%) UGT2A3;CYP26B1;CYP3A7;...
NF-kappa B signaling pathway -1.76 1.27e-2 90/104 (86.54%) GADD45B;TRAF1;GADD45A;...
Ribosome -1.77 1.15e-2 113/158 (71.52%) RPL35;RPL13A;RPL36A;...
TNF signaling pathway -1.79 8.76e-3 103/112 (91.96%) CCL2;CREB3;IKBKB;...
Non-alcoholic fatty liver disease -1.79 9.49e-3 126/155 (81.29%) NDUFS7;NDUFA8;FAS;...
Coronavirus disease -1.80 1.04e-2 215/232 (92.67%) VWF;OAS2;CHUK;...
Rheumatoid arthritis -1.84 8.54e-3 78/93 (83.87%) ATP6V1E1;ATP6V0C;ATP6V1H;...
Chemokine signaling pathway -1.84 8.43e-3 163/192 (84.9%) ADCY8;CHUK;SOS2;...
Cytokine-cytokine receptor interaction -1.87 5.93e-3 246/295 (83.39%) TNFRSF1A;CCL5;IL18RAP;...
Epithelial cell signaling in Helicobacter pylori infect... -1.89 5.42e-3 62/70 (88.57%) MAPK10;ATP6V1E1;ATP6V0C;...
IL-17 signaling pathway -1.90 4.74e-3 84/94 (89.36%) CXCL3;CCL11;IL1B;...
Legionellosis -1.99 0.00e+0 51/57 (89.47%) CD14;NFKBIA;HSPA1A;...
Pertussis -2.05 0.00e+0 64/76 (84.21%) C2;IL1A;GNAI3;...
Oxidative phosphorylation -2.06 0.00e+0 93/133 (69.92%) ATP5MC1;NDUFB11;ATP5F1C;...
Complement and coagulation cascades -2.32 0.00e+0 76/85 (89.41%) TFPI;C7;PLG;...
Viral protein interaction with cytokine and cytokine re... -2.43 0.00e+0 84/100 (84%) CCL7;CCL8;CCR1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 3.33uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 3.33uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H