Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMS104F)

Drug Name
Temsirolimus Drug Info
Synonyms Torisel
Cross-matching ID
PubChem CID
6918289
ChEBI ID
CHEMBL1201182
CAS Number
CAS 162635-04-3
TTD Drug ID
D0ES1Q
VARIDT Drug ID
DR00432
INTEDE Drug ID
DR1548
ACDINA Drug ID
D01471

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
ECM-receptor interaction 2.12 0.00e+0 80/88 (90.91%) ITGB5;THBS1;THBS3;...
TGF-beta signaling pathway 1.82 3.97e-2 81/94 (86.17%) MYC;INHBA;TGIF1;...
Proteoglycans in cancer 1.79 4.30e-2 172/205 (83.9%) MYC;ITGB5;IGF1R;...
Transcriptional misregulation in cancer 1.78 3.73e-2 158/192 (82.29%) MYC;DUSP6;IGF1R;...
Sulfur metabolism 1.77 3.18e-2 9/10 (90%) PAPSS2;TST;MPST;...
MicroRNAs in cancer 1.75 3.48e-2 146/310 (47.1%) MYC;IRS2;IRS1;...
Notch signaling pathway 1.71 4.12e-2 49/59 (83.05%) RFNG;JAG1;NCSTN;...
Focal adhesion 1.70 4.22e-2 180/201 (89.55%) ITGB5;IGF1R;PDGFD;...
Coronavirus disease 1.68 4.86e-2 215/232 (92.67%) MX2;RPL36;IRF9;...
Glycolysis / Gluconeogenesis -1.61 4.33e-2 56/67 (83.58%) ADH5;PGM1;ENO1;...
Pyruvate metabolism -1.62 3.75e-2 41/47 (87.23%) ALDH2;ME2;ADH5;...
Legionellosis -1.62 3.93e-2 51/57 (89.47%) IL18;CASP1;CASP3;...
Glycine, serine and threonine metabolism -1.65 3.52e-2 31/40 (77.5%) GCAT;GLDC;CBS;...
PPAR signaling pathway -1.66 3.18e-2 66/74 (89.19%) ACSL1;ACAA1;FABP5;...
Spliceosome -1.70 2.46e-2 101/150 (67.33%) RBM25;SRSF4;DHX15;...
Aminoacyl-tRNA biosynthesis -1.70 2.55e-2 15/66 (22.73%) IARS2;GATC;NARS2;...
Cysteine and methionine metabolism -1.71 2.52e-2 43/50 (86%) BHMT2;KYAT3;GOT2;...
Arginine and proline metabolism -1.71 2.55e-2 39/50 (78%) ALDH2;GOT2;OAT;...
Fructose and mannose metabolism -1.75 1.65e-2 30/33 (90.91%) TPI1;ALDOA;PFKP;...
Huntington disease -1.75 1.78e-2 233/306 (76.14%) CASP3;AP2S1;PSMB1;...
Amyotrophic lateral sclerosis -1.83 6.71e-3 267/364 (73.35%) PPP3CC;CASP3;PSMB1;...
Prion disease -1.85 5.49e-3 209/273 (76.56%) PPP3CC;CASP3;PSMB1;...
RNA transport -1.87 5.04e-3 128/186 (68.82%) NUP188;PRMT5;SAP18;...
Protein processing in endoplasmic reticulum -1.89 3.36e-3 127/171 (74.27%) SEC23A;BAK1;HYOU1;...
Spinocerebellar ataxia -1.89 3.78e-3 128/143 (89.51%) PSMB1;RORA;PSMA5;...
Terpenoid backbone biosynthesis -1.98 1.44e-3 18/22 (81.82%) GGPS1;MVK;FDPS;...
Citrate cycle (TCA cycle) -2.03 1.68e-3 30/30 (100%) PDHA1;SDHB;DLAT;...
Parkinson disease -2.04 2.01e-3 176/249 (70.68%) SLC25A4;ADRM1;PSMC5;...
Biosynthesis of unsaturated fatty acids -2.09 0.00e+0 21/27 (77.78%) ACOT7;ACAA1;ELOVL6;...
Steroid biosynthesis -2.21 0.00e+0 19/20 (95%) FDFT1;HSD17B7;EBP;...
Ribosome biogenesis in eukaryotes -2.23 0.00e+0 52/108 (48.15%) PWP2;TCOF1;NOL6;...
Proteasome -2.54 0.00e+0 44/46 (95.65%) PSMB1;PSMA5;PSMD8;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 10uM 6H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 10uM 6H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 10uM 6H
MDST8 CVCL_1400 Homo sapiens 10uM 6H
NCI-H508 CVCL_1561 Homo sapiens 10uM 6H
SNU-1040 CVCL_5001 Homo sapiens 10uM 6H
SNU-C4 CVCL_5008 Homo sapiens 10uM 6H
SNU-C5 CVCL_5009 Homo sapiens 10uM 6H
SW480 CVCL_0546 Homo sapiens 10uM 6H
SW620 CVCL_0547 Homo sapiens 10uM 6H
SW948 CVCL_0550 Homo sapiens 10uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 10uM 6H
HT115 CVCL_1294 Homo sapiens 10uM 6H
RKO CVCL_0504 Homo sapiens 10uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 10uM 6H
SNG-M CVCL_1707 Homo sapiens 10uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
DV-90 CVCL_1184 Homo sapiens 10uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 10uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 10uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 10uM 6H
T3M-10 CVCL_1729 Homo sapiens 10uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 10uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 10uM 6H
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 10uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 10uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 10uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 10uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 10uM 6H
OV7 CVCL_1623 Homo sapiens 10uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 10uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 10uM 6H
RMUG-S CVCL_1666 Homo sapiens 10uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 10uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 10uM 6H
PL-21 CVCL_2161 Homo sapiens 10uM 6H
SKM-1 CVCL_0010 Homo sapiens 10uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 10uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 10uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 10uM 6H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H