Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMS3CBD)

• Drug Name: geraniol Drug Info
• Synonyms: GERANIOL; 106-24-1; Lemonol; Geranyl alcohol; trans-Geraniol; (E)-Geraniol; (2E)-3,7-dimethylocta-2,6-dien-1-ol; (E)-Nerol; trans-3,7-Dimethyl-2,6-octadien-1-ol; (E)-3,7-Dimethylocta-2,6-dien-1-ol; Geraniol Extra; Geraniol alcohol; 3,7-Dimethyl-2,6-octadien-1-ol; (E)-3,7-Dimethyl-2,6-octadien-1-ol; beta-Geraniol; 3,7-Dimethyl-trans-2,6-octadien-1-ol; 2,6-Octadien-1-ol, 3,7-dimethyl-, (2E)-; Guaniol; t-geraniol; 2E-geraniol; Geraniol (natural); 2-trans-3,7-Dimethyl-2,6-octadien-1-ol; 2,6-Octadien-1-ol, 3,7-dimethyl-; CHEBI:17447
• Cross-matching ID:
  PubChem CID: 637566
  ChEBI ID: CHEMBL25719
  CAS Number: CAS 106-24-1
  TTD Drug ID: D0Q4GB

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Cardiac muscle contraction	1.93	2.31e-2	64/87 (73.56%)	ATP1B3;CASQ2;ACTC1;...
Vascular smooth muscle contraction	1.82	4.34e-2	113/133 (84.96%)	GNAS;PLA2G2A;MYH11;...
Steroid biosynthesis	1.82	3.47e-2	19/20 (95%)	NSDHL;LSS;SOAT1;...
Adrenergic signaling in cardiomyocytes	1.76	4.44e-2	130/150 (86.67%)	GNAS;PLN;PPP2R5E;...
Thyroid hormone synthesis	1.76	3.80e-2	66/75 (88%)	GNAS;ATP1B3;PLCB4;...
Oxidative phosphorylation	1.74	4.20e-2	93/133 (69.92%)	ATP6V0E2;COX5A;COX6C;...
Protein export	1.74	3.73e-2	17/23 (73.91%)	SEC61A1;SPCS3;OXA1L;...
Dilated cardiomyopathy	1.73	3.59e-2	86/96 (89.58%)	GNAS;PLN;DES;...
Complement and coagulation cascades	1.71	3.89e-2	76/85 (89.41%)	C7;C3;FGG;...
PPAR signaling pathway	1.71	3.86e-2	66/74 (89.19%)	HMGCS1;FABP5;FABP4;...
Vibrio cholerae infection	1.70	3.65e-2	44/50 (88%)	GNAS;ATP6V0E2;PLCG1;...
Diabetic cardiomyopathy	1.70	3.72e-2	162/203 (79.8%)	PLN;GYS1;PLCB4;...
Tyrosine metabolism	1.68	4.94e-2	30/36 (83.33%)	ADH1B;AOC3;AOX1;...
Hedgehog signaling pathway	1.68	4.63e-2	43/56 (76.79%)	GAS1;SPOP;GLI3;...
Biosynthesis of unsaturated fatty acids	1.67	4.77e-2	21/27 (77.78%)	FADS1;ACAA1;SCD;...
Arginine and proline metabolism	1.66	4.89e-2	39/50 (78%)	MAOA;CKB;ALDH9A1;...
SNARE interactions in vesicular transport	-1.90	2.31e-2	19/33 (57.58%)	STX4;STX8;VAMP1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	20uM	6H	Hide ▲

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	20uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	20uM	6H, 24H	Show ▼