Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMS3HNM)

Drug Name
Jte 013 Drug Info
Synonyms
Jte 013; JTE-013; 383150-41-2; CHEMBL1368758; S1P2 Receptor Antagonist, JTE-013; N-(2,6-dichloropyridin-4-yl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazinecarboxamide; 1-(2,6-dichloropyridin-4-yl)-3-[(1,3-dimethyl-4-propan-2-ylpyrazolo[3,4-b]pyridin-6-yl)amino]urea; 1-(1,3-Dimethyl-4-isopropyl)-1H-pyrazolo[3,4-b]pyridin-6-yl)-4-(3,5-dichloro-4-pyridinyl)-semicarbazide; pyrazolopyridine analog; C17H19Cl2N7O; GTPL2917; SCHEMBL5911940; CHEBI:92763; CTK8F0047; SYN5010; DTXSID60436982; AOB1935; HMS3650O12;
Cross-matching ID
PubChem CID
10223146
ChEBI ID
CHEMBL1368758
CAS Number
CAS 383150-41-2
TTD Drug ID
D0K4BI

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Nicotine addiction 1.97 2.27e-2 32/40 (80%) GRIA2;GABRB3;CACNA1A;...
Intestinal immune network for IgA production 1.87 3.98e-2 38/48 (79.17%) CD40;CXCL12;IL6;...
Arachidonic acid metabolism 1.82 4.55e-2 48/61 (78.69%) AKR1C3;GPX2;PLAAT3;...
beta-Alanine metabolism 1.80 3.98e-2 25/30 (83.33%) ALDH3A1;ALDH2;GAD2;...
Nitrogen metabolism 1.78 3.86e-2 16/17 (94.12%) CA12;GLUL;CA9;...
Galactose metabolism 1.78 3.22e-2 26/31 (83.87%) AKR1B10;HK2;UGP2;...
Asthma 1.76 3.90e-2 25/31 (80.65%) CD40;FCER1G;HLA-DRB1;...
DNA replication -1.91 8.49e-3 34/36 (94.44%) DNA2;LIG1;RFC2;...
Steroid biosynthesis -2.11 0.00e+0 19/20 (95%) CYP24A1;LIPA;SQLE;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H