Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMS4D96)

Drug Name
imiloxan Drug Info
Synonyms RS-21361; GNF-Pf-2156
Cross-matching ID
PubChem CID
133621
ChEBI ID
CHEMBL91522
CAS Number
CAS 81167-16-0
TTD Drug ID
D03IVG

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Proteasome 2.22 0.00e+0 44/46 (95.65%) PSMA6;PSMD14;PSMA5;...
Oxidative phosphorylation 2.12 0.00e+0 93/133 (69.92%) NDUFB5;ATP5F1C;COX7B;...
Huntington disease 1.92 9.85e-3 233/306 (76.14%) CYCS;PSMA6;NDUFB5;...
Mineral absorption 1.91 9.23e-3 48/60 (80%) STEAP1;MT1M;MT1E;...
Parkinson disease 1.86 1.48e-2 176/249 (70.68%) CYCS;UCHL1;PSMA6;...
Prion disease 1.79 2.22e-2 209/273 (76.56%) CYCS;PSMA6;NDUFB5;...
Ribosome 1.76 2.53e-2 113/158 (71.52%) MRPL15;MRPL13;MRPS12;...
Amyotrophic lateral sclerosis 1.75 2.40e-2 267/364 (73.35%) CYCS;PSMA6;NDUFB5;...
Human papillomavirus infection -1.82 4.54e-2 284/331 (85.8%) COL2A1;PPP2R3A;MFNG;...
Insulin resistance -1.84 3.89e-2 96/108 (88.89%) MLXIPL;PRKCB;CREB3L1;...
Dilated cardiomyopathy -1.89 2.60e-2 86/96 (89.58%) CACNA2D2;TTN;ITGB3;...
Regulation of lipolysis in adipocytes -1.91 3.89e-2 52/55 (94.55%) PLAAT3;PIK3CD;PIK3R3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H