Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMS610L)

Drug Name
PF-04691502 Drug Info
Synonyms
PF-04691502; 1013101-36-4; PF 04691502; UNII-4W39NS61KI; 4W39NS61KI; 2-amino-8-((1r,4r)-4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one; CHEMBL1234354; PF04691502; 2-Amino-8-[trans-4-(2-Hydroxyethoxy)cyclohexyl]-6-(6-Methoxypyridin-3-Yl)-4-Methylpyrido[2,3-D]pyrimidin-7(8h)-One; 2-Amino-8-[4-(2-hydroxyethoxy)cyclohexyl]-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin-7-one
Cross-matching ID
PubChem CID
25033539
ChEBI ID
CHEMBL5278357
CAS Number
CAS 1013101-36-4
TTD Drug ID
D0N5JZ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Other glycan degradation 1.79 4.95e-2 13/18 (72.22%) ENGASE;HEXB;AGA;...
Cell cycle -1.59 4.75e-2 110/124 (88.71%) GADD45G;MCM3;CDC23;...
Glycolysis / Gluconeogenesis -1.63 3.62e-2 56/67 (83.58%) ENO2;PDHA1;PFKM;...
PPAR signaling pathway -1.64 3.22e-2 66/74 (89.19%) PDPK1;ACADL;HMGCS2;...
RNA polymerase -1.68 2.22e-2 23/31 (74.19%) POLR2L;POLR2F;POLR2E;...
Collecting duct acid secretion -1.69 2.17e-2 22/27 (81.48%) ATP6V0C;ATP6V1C1;ATP4A;...
Cysteine and methionine metabolism -1.71 1.96e-2 43/50 (86%) ENOPH1;DNMT1;LDHA;...
Glutathione metabolism -1.72 1.57e-2 43/57 (75.44%) GSTA4;ANPEP;GPX3;...
Fructose and mannose metabolism -1.73 1.65e-2 30/33 (90.91%) KHK;AKR1B1;PFKM;...
Toll-like receptor signaling pathway -1.74 1.61e-2 94/104 (90.38%) TOLLIP;TBK1;JUN;...
Epstein-Barr virus infection -1.77 1.39e-2 189/202 (93.56%) PSMC5;BID;MAPK10;...
Spinocerebellar ataxia -1.77 1.47e-2 128/143 (89.51%) MAPK10;PSMB5;PSMA5;...
Ribosome biogenesis in eukaryotes -1.78 1.42e-2 52/108 (48.15%) NOP10;IMP4;SNU13;...
Cytosolic DNA-sensing pathway -1.80 1.14e-2 52/63 (82.54%) CASP1;POLR2L;TBK1;...
Glycine, serine and threonine metabolism -1.83 7.30e-3 31/40 (77.5%) SHMT1;SHMT2;GCAT;...
Terpenoid backbone biosynthesis -1.83 7.86e-3 18/22 (81.82%) PDSS2;HMGCS2;MVD;...
Legionellosis -1.85 6.62e-3 51/57 (89.47%) HSPA8;TLR4;ITGAM;...
Folate biosynthesis -1.85 5.16e-3 23/26 (88.46%) AKR1B1;TPH1;MOCOS;...
Amyotrophic lateral sclerosis -1.88 4.54e-3 267/364 (73.35%) COX7B;NDUFA8;ACTR1A;...
Huntington disease -1.90 2.52e-3 233/306 (76.14%) MTOR;GPX3;ATP5MC1;...
Protein processing in endoplasmic reticulum -1.95 1.42e-3 127/171 (74.27%) HSPA8;RRBP1;SEC63;...
Biosynthesis of unsaturated fatty acids -1.96 1.62e-3 21/27 (77.78%) HACD3;HSD17B12;HACD2;...
Citrate cycle (TCA cycle) -1.97 1.89e-3 30/30 (100%) FH;IDH1;ACLY;...
DNA replication -1.98 2.27e-3 34/36 (94.44%) PRIM2;RNASEH2A;POLD1;...
Parkinson disease -2.09 0.00e+0 176/249 (70.68%) COX7B;NDUFA8;NDUFA9;...
Prion disease -2.10 0.00e+0 209/273 (76.56%) COX7B;NDUFA8;NDUFA9;...
Steroid biosynthesis -2.27 0.00e+0 19/20 (95%) HSD17B7;FDFT1;SOAT1;...
Proteasome -2.58 0.00e+0 44/46 (95.65%) PSMB5;PSMA5;PSMB2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
K-562 CVCL_0004 Homo sapiens 0.01uM - 10uM 4H, 24H
Multiple myeloma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
KMS-34 CVCL_1333 Homo sapiens 0.01uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Lymph node
Burkitt lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BJAB CVCL_5711 Homo sapiens 0.01uM - 10uM 24H
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HBL-1 CVCL_4213 Homo sapiens 0.01uM - 10uM 4H, 24H
OCI-Ly19 CVCL_8797 Homo sapiens 0.01uM - 10uM 4H, 24H
OCI-Ly3 CVCL_8796 Homo sapiens 0.01uM - 10uM 4H, 24H
TMD8 CVCL_A440 Homo sapiens 0.01uM - 10uM 4H, 24H
Mantle cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MINO CVCL_4965 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute B-lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NALM-6 CVCL_0092 Homo sapiens 0.01uM - 10uM 24H
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
SK-MEL-5 CVCL_0527 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H