Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMS6IJ0)

Drug Name
RHEIN Drug Info
Synonyms
Rhein; 478-43-3; Monorhein; Rheic acid; Rhubarb Yellow; Cassic acid; 4,5-Dihydroxyanthraquinone-2-carboxylic acid; Chrysazin-3-carboxylic acid; 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid; NSC 38629; Rheinic acid; 1,8-Dihydroxyanthraquinone-3-carboxylic acid; dipropionyl rhein; 1,8-Dihydroxy-3-carboxyanthraquinone; UNII-YM64C2P6UX; Rhein(Monorhein); 2-Anthracenecarboxylic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-; CCRIS 5129; 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid; C15H8O6
Cross-matching ID
PubChem CID
10168
ChEBI ID
CHEMBL8825
CAS Number
CAS 478-43-3
TTD Drug ID
D0M2TY

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Cell cycle 1.94 9.95e-3 110/124 (88.71%) CCNB1;CCNA2;BUB3;...
Caffeine metabolism 1.77 3.73e-2 5/6 (83.33%) NAT1;CYP1A2;CYP2A6;...
Ferroptosis -1.67 3.09e-2 36/41 (87.8%) ATG7;ACSL4;SLC39A8;...
Cortisol synthesis and secretion -1.68 3.03e-2 58/65 (89.23%) CYP17A1;PDE8B;CACNA1S;...
Aldosterone synthesis and secretion -1.69 2.91e-2 85/98 (86.73%) CAMK2A;KCNK3;ATP1B3;...
Purine metabolism -1.71 2.67e-2 102/129 (79.07%) PDE1B;IMPDH1;PDE8A;...
Regulation of lipolysis in adipocytes -1.72 2.35e-2 52/55 (94.55%) ADCY8;ADRB3;PLIN1;...
Leishmaniasis -1.74 2.01e-2 67/77 (87.01%) IL4;FOS;TGFB1;...
Cholinergic synapse -1.74 2.03e-2 99/113 (87.61%) CACNA1S;FOS;PIK3CG;...
Retrograde endocannabinoid signaling -1.74 1.98e-2 118/148 (79.73%) GNAI1;NDUFS3;GNG10;...
Amino sugar and nucleotide sugar metabolism -1.75 1.85e-2 38/48 (79.17%) CYB5R2;GALK1;NPL;...
Neutrophil extracellular trap formation -1.76 1.64e-2 101/189 (53.44%) AGER;ACTB;PIK3R3;...
Asthma -1.79 1.26e-2 25/31 (80.65%) RNASE3;FCER1A;HLA-DQA1;...
Pentose phosphate pathway -1.80 1.07e-2 25/30 (83.33%) RPIA;GPI;RBKS;...
Vibrio cholerae infection -1.81 7.84e-3 44/50 (88%) ATP6V1F;TJP1;ACTB;...
Fatty acid elongation -1.82 7.38e-3 19/27 (70.37%) HACD2;ELOVL1;ECHS1;...
Hematopoietic cell lineage -1.82 7.84e-3 90/99 (90.91%) CD7;CD1D;GYPA;...
Hypertrophic cardiomyopathy -1.82 6.28e-3 81/90 (90%) DAG1;SGCG;ITGB6;...
Cell adhesion molecules -1.83 6.72e-3 118/148 (79.73%) HLA-DQA1;HLA-G;CLDN10;...
Tryptophan metabolism -1.83 4.83e-3 35/42 (83.33%) ALDH2;GCDH;DHTKD1;...
Glycerolipid metabolism -1.84 5.23e-3 44/61 (72.13%) ALDH2;AGPAT4;PNPLA2;...
Endocrine and other factor-regulated calcium reabsorpti... -1.85 4.28e-3 49/53 (92.45%) TRPV5;ATP1B3;ATP1A1;...
Morphine addiction -1.86 4.71e-3 80/91 (87.91%) GNAI1;GNG10;PDE1B;...
beta-Alanine metabolism -1.86 5.23e-3 25/30 (83.33%) AOC2;ABAT;ALDH2;...
Dilated cardiomyopathy -1.90 5.88e-3 86/96 (89.58%) ACTB;TGFB1;ADCY3;...
Viral myocarditis -1.99 4.48e-3 53/60 (88.33%) RAC3;ACTB;CD40;...
Galactose metabolism -1.99 5.23e-3 26/31 (83.87%) LALBA;G6PC3;GLB1;...
Autoimmune thyroid disease -2.01 3.14e-3 46/53 (86.79%) PRF1;HLA-DQA1;FAS;...
Type I diabetes mellitus -2.12 0.00e+0 38/43 (88.37%) PRF1;HLA-DQA1;IFNG;...
Graft-versus-host disease -2.30 0.00e+0 32/42 (76.19%) KLRD1;PRF1;HLA-DQA1;...
Allograft rejection -2.40 0.00e+0 32/38 (84.21%) PRF1;HLA-DQA1;IFNG;...
Antigen processing and presentation -2.42 0.00e+0 60/78 (76.92%) KLRD1;PSME2;NFYA;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H