Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMS7T13)

Drug Name
Meclizine Drug Info
Synonyms
Ancolan; Ancolon; Antivert; Bonadettes; Bonine; Calmonal; Chiclida; Diadril; Histamethine; Histamethizine; Histametizine; Histametizyn; Histametizyne; Itinerol; Marex; Meclicot; Meclozina; Meclozine; Meclozinum; Medivert; Monamine; Navicalm; Nevidoxine; Parachloramine; Peremesin; Postafene; Ravelon; Sabari; Siguran; Subari; Suprimal; Travelon; Veritab; Vomisseis; Vomissels; Dramamine II; Meclizine Hcl; UCB 170; UCB 5052; UCB 5062; Antivert (TN); Antivert/25; Antivert/50; Bonamine (TN); Bonine (TN); Meclizine [INN:BAN]; Meclozina [INN-Spanish]; Meclozine (BAN); Meclozinum [INN-Latin]; Neo-istafene; Neo-suprimal; Neo-suprimel; Nevidoxine (TN); Postafen (TN); Sea-Legs; Ru-Vert-M; U. C. B. 5062; U.C.B. 5062; (+-)-Meclizine; 1-((4-Chlorophenyl)phenylmethyl)-4-((3-methylphenyl)methyl)piperazine; 1-(p-Chloro-.alpha.-phenylbenzyl)-4-(m-methylbenzyl)piperazine; 1-(p-Chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)piperazine; 1-(p-Chlorobenzhydryl)-4-(m-methylbenzyl)diethylenediamine; 1-(p-Chlorobenzhydryl)-4-(m-methylbenzyl)piperazine; 1-[(4-chlorophenyl)(phenyl)methyl]-4-[(3-methylphenyl)methyl]piperazine; 1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine; 1-p-Chlorobenzhydryl-4-m-methylbenzylpiperazine
Therapeutic ClassAntiallergic Agents
Cross-matching ID
PubChem CID
4034
ChEBI ID
CHEMBL1623
CAS Number
CAS 569-65-3
TTD Drug ID
D0T1XW
VARIDT Drug ID
DR00977
INTEDE Drug ID
DR1006
ACDINA Drug ID
D00387

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Asthma 2.21 0.00e+0 25/31 (80.65%) CD40;HLA-DMB;HLA-DPA1;...
DNA replication 2.04 5.43e-3 34/36 (94.44%) PCNA;MCM5;MCM2;...
Intestinal immune network for IgA production 1.95 3.62e-3 38/48 (79.17%) CD40;HLA-DMB;HLA-DPA1;...
Allograft rejection 1.94 2.72e-3 32/38 (84.21%) CD40;HLA-DMB;HLA-DPA1;...
Ribosome biogenesis in eukaryotes 1.88 1.52e-2 52/108 (48.15%) NVL;NOP56;RAN;...
Primary immunodeficiency 1.86 1.45e-2 33/38 (86.84%) CD40;IL7R;BLNK;...
Systemic lupus erythematosus 1.80 2.02e-2 45/135 (33.33%) CD40;HLA-DMB;HLA-DPA1;...
Autoimmune thyroid disease 1.78 2.44e-2 46/53 (86.79%) CD40;HLA-DMB;HLA-DPA1;...
Graft-versus-host disease 1.75 2.66e-2 32/42 (76.19%) HLA-DMB;HLA-DPA1;HLA-DQA1;...
Spliceosome 1.73 3.26e-2 101/150 (67.33%) HSPA8;LSM5;SNRPB;...
Pyrimidine metabolism 1.73 3.06e-2 40/56 (71.43%) ENTPD1;RRM2;RRM1;...
Antigen processing and presentation 1.71 2.90e-2 60/78 (76.92%) HSPA8;HSPA4;HLA-DMB;...
Toxoplasmosis 1.71 3.18e-2 103/112 (91.96%) HSPA8;CD40;ALOX5;...
Protein digestion and absorption 1.70 3.49e-2 78/103 (75.73%) COL4A5;COL4A6;SLC7A8;...
Type I diabetes mellitus 1.69 3.62e-2 38/43 (88.37%) HLA-DMB;HLA-DPA1;HLA-DQA1;...
PPAR signaling pathway -1.98 2.69e-2 66/74 (89.19%) ACSL3;UBC;HMGCS2;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H