Details of the Drug Pharmacogenomic Perturbation Atlas

Geldanamycin Drug Info

GDM; GMY; Geldanamicin; Geldanomycin; Geldaramycin; Antibiotic U 29135; BODIPY-labeled Geldanamycin; Geldanamycin (9CI); Geldanamycin, Streptomyces hygroscopicus; U-29135; Antibiotic (U-29,135); [(8E,12E,14Z)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate; [(8E,12Z,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate; [(8Z,12Z,14Z)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate; [(3R,5R,6S,7R,10R,11R)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate; [(3R,5S,6R,7S,10R,11R)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate; [(3R,5S,6R,7S,10S,11S)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate; [(3S,5S,6R,7S,8E,10R,11S,12Z,14E)-6-Hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-8,12,14,18,21-pentaen-10-yl] carbamate; [(3R,5R,6S,7R,8E,10R,11R,12Z,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate; [(3R,5S,6R,7S,8E,10R,11R,12Z,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate; [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate; [(3S,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate; (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate; (6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl) carbamate; [8S-(4E,6Z,8R*,9R*,10E,12R*,13S*,14R*,16S*)]-9-[(Aminocarbonyl)oxy]-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione; 2-Azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-, 9-carbamate (8CI); 2-Azabicyclo[16.3.1]docosane, geldanamycin deriv.

Cross-matching ID

PubChem CID

5288382

ChEBI ID

CHEMBL278315

CAS Number

CAS 30562-34-6

TTD Drug ID

D03PKI

General Information of Drug (ID: DMS7TC5)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Protein processing in endoplasmic reticulum	2.83	0.00e+0	127/171 (74.27%)	HSPA1A;HSPA6;HSPH1;...
Antigen processing and presentation	2.42	0.00e+0	60/78 (76.92%)	HSPA1A;HSPA6;HSPA8;...
Longevity regulating pathway	2.10	0.00e+0	90/151 (59.6%)	HSPA1A;HSPA6;HSPA8;...
Legionellosis	2.09	0.00e+0	51/57 (89.47%)	HSPA1A;HSPA6;HSPA8;...
Spliceosome	2.03	0.00e+0	101/150 (67.33%)	HSPA1A;HSPA6;HSPA8;...
Protein export	1.97	4.45e-3	17/23 (73.91%)	HSPA5;SEC63;SRP14;...
Ferroptosis	1.88	1.40e-2	36/41 (87.8%)	FTH1;HMOX1;SLC11A2;...
Estrogen signaling pathway	1.80	2.45e-2	119/137 (86.86%)	HSPA1A;HSPA6;HSPA8;...
Arginine biosynthesis	1.76	3.26e-2	17/22 (77.27%)	GLUL;GLUD1;ASS1;...
Mitophagy	1.76	3.03e-2	56/68 (82.35%)	GABARAPL1;CITED2;EIF2AK3;...
Collecting duct acid secretion	1.75	3.24e-2	22/27 (81.48%)	SLC12A7;ATP6V1A;ATP6V1G1;...
Vibrio cholerae infection	1.72	3.64e-2	44/50 (88%)	PDIA4;KDELR1;ARF1;...
Prion disease	1.72	3.49e-2	209/273 (76.56%)	HSPA1A;HSPA6;HSPA8;...
Lysosome	1.69	4.07e-2	115/128 (89.84%)	LITAF;SLC11A2;NEU1;...
Cell cycle	-1.85	5.58e-3	110/124 (88.71%)	ATR;PKMYT1;CCNE1;...
Pyrimidine metabolism	-1.88	1.60e-3	40/56 (71.43%)	NT5M;CDA;ENTPD3;...
Nucleotide excision repair	-1.93	1.86e-3	40/47 (85.11%)	POLD3;GTF2H1;RAD23A;...
Homologous recombination	-2.22	0.00e+0	35/41 (85.37%)	RAD54L;TOPBP1;POLD3;...
Mismatch repair	-2.28	0.00e+0	22/23 (95.65%)	MSH6;POLD3;MSH2;...
Base excision repair	-2.30	0.00e+0	29/33 (87.88%)	POLD3;MUTYH;POLB;...
Fanconi anemia pathway	-2.34	0.00e+0	36/54 (66.67%)	FAN1;TELO2;RPA2;...
DNA replication	-2.80	0.00e+0	34/36 (94.44%)	POLD3;POLA1;RPA2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Ewing sarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-673	CVCL_0080	Homo sapiens	10uM	6H

Nasopharyngeal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
NPC-B13	CVCL_D3FG	Homo sapiens	10uM	XH

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	20uM	6H

Bone marrow

Nasopharyngeal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
NPC-BM00	CVCL_B3QC	Homo sapiens	10uM	XH

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
MCF7	CVCL_0031	Homo sapiens	0.002uM - 20uM	3H, 6H, 24H

MDA-MB-231	CVCL_0062	Homo sapiens	0.04uM - 10uM	3H, 24H

SK-BR-3	CVCL_0033	Homo sapiens	0.04uM - 10uM	3H, 24H

Breast carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
BT-20	CVCL_0178	Homo sapiens	0.04uM - 10uM	3H, 24H

Hs 578T	CVCL_0332	Homo sapiens	0.04uM - 10uM	3H, 24H

Normal (Epithelial)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HME1	CVCL_2950	Homo sapiens	0.04uM - 10uM	3H, 24H

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.04uM - 10uM	3H, 24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
CL-34	CVCL_1123	Homo sapiens	10uM	6H

HT-29	CVCL_0320	Homo sapiens	0.04uM - 10uM	6H, 24H

LoVo	CVCL_0399	Homo sapiens	10uM	6H

MDST8	CVCL_1400	Homo sapiens	10uM	6H

NCI-H508	CVCL_1561	Homo sapiens	10uM	6H

SNU-1040	CVCL_5001	Homo sapiens	10uM	6H

SNU-C4	CVCL_5008	Homo sapiens	10uM	6H

SNU-C5	CVCL_5009	Homo sapiens	10uM	6H

SW480	CVCL_0546	Homo sapiens	10uM	6H

SW620	CVCL_0547	Homo sapiens	10uM	6H

SW948	CVCL_0550	Homo sapiens	10uM	6H

Colorectal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
HCT 116	CVCL_0291	Homo sapiens	10uM	6H

HT115	CVCL_1294	Homo sapiens	10uM	6H

RKO	CVCL_0504	Homo sapiens	10uM	6H

Endometrium

Endometrial adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
HEC-108	CVCL_2926	Homo sapiens	10uM	6H

SNG-M	CVCL_1707	Homo sapiens	10uM	6H

Endometrial carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
JHUEM-2	CVCL_1327	Homo sapiens	10uM	6H

Fibroblast

Nasopharyngeal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
FIBRNPC	CVCL_UK07	Homo sapiens	10uM	6H, 24H

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.04uM - 10uM	6H, 24H

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
1HAEo-	CVCL_0128	Homo sapiens	0.04uM - 10uM	24H

NL20	CVCL_0461	Homo sapiens	0.04uM - 10uM	24H

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	0.04uM - 20uM	3H, 6H, 24H

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	10uM	6H, 24H

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
NPC2-hTERT	CVCL_B6EI	Homo sapiens	10uM	XH

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
A549	CVCL_0023	Homo sapiens	0.002uM - 20uM	6H, 24H

DV-90	CVCL_1184	Homo sapiens	10uM	6H

SK-LU-1	CVCL_0624	Homo sapiens	10uM	6H

Lung adenosquamous carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
NCI-H596	CVCL_1571	Homo sapiens	10uM	6H

Lung large cell carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
COR-L23	CVCL_1133	Homo sapiens	10uM	6H

T3M-10	CVCL_1729	Homo sapiens	10uM	6H

Lung squamous cell carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC15	CVCL_1253	Homo sapiens	10uM	6H

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
NCI-H1299	CVCL_0060	Homo sapiens	10uM	6H

HCC515	CVCL_5134	Homo sapiens	0.04uM - 10uM	6H, 24H

NCI-H2073	CVCL_1523	Homo sapiens	10uM	6H

Normal (Fibroblast)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
HFL1	CVCL_4295	Homo sapiens	0.04uM - 10uM	24H

IMR-90	CVCL_0347	Homo sapiens	0.04uM - 10uM	24H

WI-38	CVCL_0579	Homo sapiens	0.04uM - 10uM	24H

Small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
NCI-H1694	CVCL_1495	Homo sapiens	10uM	6H

NCI-H1836	CVCL_1502	Homo sapiens	10uM	6H

Lymph node

Diffuse large B-cell lymphoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
WSU-DLCL2	CVCL_1787	Homo sapiens	10uM	6H

Ovary

Ovarian carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
EFO-27	CVCL_1194	Homo sapiens	10uM	6H

OV7	CVCL_1623	Homo sapiens	10uM	6H

Ovarian clear cell carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
RMG-I	CVCL_1663	Homo sapiens	10uM	6H

Ovarian mucinous cystadenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
COV644	CVCL_2011	Homo sapiens	10uM	6H

RMUG-S	CVCL_1666	Homo sapiens	10uM	6H

Ovarian undifferentiated carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
TYK-nu	CVCL_1774	Homo sapiens	10uM	6H

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	2.22uM	6H

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	10uM	6H

Acute myeloid leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
HL-60	CVCL_0002	Homo sapiens	0.37uM - 10uM	6H, 24H

NOMO-1	CVCL_1609	Homo sapiens	10uM	6H

PL-21	CVCL_2161	Homo sapiens	10uM	6H

SKM-1	CVCL_0010	Homo sapiens	10uM	6H

Pharynx, nasopharynx

Nasopharyngeal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
NPC-TY861	CVCL_A5WW	Homo sapiens	10uM	XH

Pleural effusion

Histiocytic lymphoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-937	CVCL_0007	Homo sapiens	0.37uM - 10uM	6H, 24H

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
LNCaP	CVCL_0395	Homo sapiens	0.04uM - 10uM	3H, 24H

PC-3	CVCL_0035	Homo sapiens	0.04uM - 10uM	6H, 24H

VCaP	CVCL_2235	Homo sapiens	0.04uM - 20uM	6H, 24H, 48H

Skin

Alzheimer's disease

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ND347327	CVCL_EZ03	Homo sapiens	10uM	XH

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
A-375	CVCL_0132	Homo sapiens	0.04uM - 10uM	6H, 24H

SK-MEL-1	CVCL_0523	Homo sapiens	10uM	6H

SK-MEL-28	CVCL_0526	Homo sapiens	10uM	6H

Stomach

Gastric adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
AGS	CVCL_0139	Homo sapiens	10uM	6H

Unclear

Nasopharyngeal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
NPC-204	CVCL_A5WV	Homo sapiens	10uM	XH

Rat sarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
XC	CVCL_1891	Rattus norvegicus (Rat)	10uM	24H