Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMS9I6A)

Drug Name
AZD7687 Drug Info
Synonyms
AZD7687; 1166827-44-6; CHEMBL2178944; CHEMBL2178953; AZD-7687; AZD 7687; UNII-6QTJ9P2NYT; 6QTJ9P2NYT; SCHEMBL2252415; SCHEMBL5532381; SCHEMBL2252417; GTPL7827; SCHEMBL2255196; DTXSID60655297; YXFNPRHZMOGREC-SHTZXODSSA-N; 3466AH; ZINC43206395; BDBM50399684; BDBM50399710; AZD 7687;AZD-7687; ZINC101581684; AKOS030526281; CS-1026; NCGC00378858-01; HY-15497; KB-144428; W-5990; {4-[4-(6-Carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]cyclohexyl}acetic acid; {trans-4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]cyclohexyl}acetic acid
Cross-matching ID
PubChem CID
42636350
ChEBI ID
CHEMBL4297354
CAS Number
CAS 1166827-44-6
TTD Drug ID
D0EY0A

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 1.93 1.37e-2 34/36 (94.44%) POLE3;RFC4;PCNA;...
Spliceosome 1.88 1.37e-2 101/150 (67.33%) HSPA1A;PRPF4;HSPA6;...
Mineral absorption 1.81 2.28e-2 48/60 (80%) STEAP1;MT1F;TF;...
Amoebiasis -1.82 2.72e-2 99/102 (97.06%) COL4A3;CD1B;CD1C;...
Inflammatory bowel disease -1.86 1.36e-2 58/65 (89.23%) MAF;TBX21;TGFB2;...
AMPK signaling pathway -1.86 1.36e-2 106/120 (88.33%) IRS2;SIRT1;PIK3R2;...
Malaria -1.91 9.08e-3 44/50 (88%) HGF;CR1;TGFB3;...
Hypertrophic cardiomyopathy -1.93 2.72e-3 81/90 (90%) SLC8A2;SGCA;SGCD;...
Rheumatoid arthritis -1.96 3.41e-3 78/93 (83.87%) CSF2;TGFB2;TNF;...
Asthma -1.99 0.00e+0 25/31 (80.65%) CCL11;PRG2;TNF;...
Dilated cardiomyopathy -2.04 0.00e+0 86/96 (89.58%) ITGA2;MYL3;TPM1;...
Hematopoietic cell lineage -2.17 0.00e+0 90/99 (90.91%) ITGA2;CSF3R;CD2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H