Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMS9R43)

Drug Name
Ecopipam Drug Info
Synonyms
Sch-39166; Sch 39166; 112108-01-7; Ecopipam [INN]; Sch39166; UNII-0X748O646K; CHEMBL298406; 0X748O646K; DSSTox_RID_80075; DSSTox_CID_23814; 6,7,7a,8,9,13b-Hexahydro-3-chloro-2-hydroxy-N-methyl-5H-benzo(d)naphtho(2,1b)azepine; DSSTox_GSID_43814; 5H-Benzo(d)naphth(2,1-b)azepin-12-ol, 11-chloro-6,6a,7,8,9,13b-hexahydro-7-methyl-, trans-(-)-; (6aS,13bR)-11-chloro-7-methyl-6,6a,7,8,9,13b-hexahydro-5H-benzo[d]naphtho[2,1-b]azepin-12-ol; 5H-Benzo[d]naphth[2,1-b]azepin-12-ol,; ecopipam (controlled-release, Lesch Nyhan syndrome/Tourette's syndrome/compulsive gambling). Psyadon Pharmaceuticals
Cross-matching ID
PubChem CID
107930
ChEBI ID
CHEMBL298406
CAS Number
CAS 112108-01-7
TTD Drug ID
D0Y6HW

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.13 0.00e+0 19/20 (95%) SQLE;DHCR24;MSMO1;...
Metabolism of xenobiotics by cytochrome P450 -1.70 3.05e-2 49/77 (63.64%) MGST2;GSTP1;GSTA4;...
Arginine biosynthesis -1.73 2.52e-2 17/22 (77.27%) NOS3;NOS2;GLS2;...
Arginine and proline metabolism -1.76 2.08e-2 39/50 (78%) PRODH;LAP3;NOS3;...
Vitamin digestion and absorption -1.79 1.65e-2 17/24 (70.83%) SLC5A6;ABCC1;APOA1;...
Glutathione metabolism -1.80 1.36e-2 43/57 (75.44%) MGST2;GSTP1;GSTA4;...
Drug metabolism -1.81 1.41e-2 78/151 (51.66%) CYP2C19;MGST2;GSTP1;...
Glycine, serine and threonine metabolism -1.84 1.32e-2 31/40 (77.5%) GNMT;PIPOX;BHMT;...
Fructose and mannose metabolism -1.85 1.38e-2 30/33 (90.91%) HK1;PFKL;MPI;...
Pentose and glucuronate interconversions -1.88 9.88e-3 17/34 (50%) KL;UGT2B15;UGDH;...
Ascorbate and aldarate metabolism -1.91 3.29e-3 15/30 (50%) ALDH9A1;KL;ALDH3A2;...
Protein processing in endoplasmic reticulum -1.93 4.94e-3 127/171 (74.27%) RAD23A;MBTPS1;MAN1A2;...
Retinol metabolism -2.03 9.88e-3 41/68 (60.29%) DHRS3;DHRS9;UGT2B4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H