Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMSC4A7)

Drug Name
Indomethacin Drug Info
Synonyms
Aconip; Amuno; Arthrexin; Artracin; Artrinovo; Artrivia; Bonidin; Bonidon; Catlep; Confortid; Dolcidium; Dolovin; Durametacin; Elmetacin; Hicin; IMN; Idomethine; Imbrilon; Inacid; Indacin; Indameth; Indmethacine; Indocid; Indocin; Indomecol; Indomed; Indomee; Indometacin; Indometacina; Indometacine; Indometacinum; Indometacyna; Indomethacine; Indomethacinum; Indomethancin; Indomethazine; Indomethegan; Indomethine; Indometicina; Indomo; Indomod; Indoptic; Indoptol; Indorektal; Indoxen; Inflazon; Infrocin; Lausit; Liometacen; Metacen; Metartril; Methazine; Metindol; Mezolin; Miametan; Mikametan; Mobilan; Novomethacin; Reumacide; Sadoreum; Tannex; Vonum; Bonidon Gel; DESMETHYL INDOMETHACIN; Dolcidium PL;Flexin continus; Indocid Pda; Indocid Sr; Indocin Sr; Indolar SR; Indometacyna [Polish]; Indometicina [Spanish]; Inteban sp; Rhemacin LA; Rheumacin LA; I 7378; IN1454; Indomet 140; Aconip (TN); Apo-Indomethacin; Chibro-amuno; Chrono-indicid; Chrono-indocid; Indo-Lemmon; Indo-Spray; Indo-phlogont; Indo-rectolmin; Indo-tablinen; Indocid (TN); Indocid (pharmaceutical); Indocin (TN); Indocin I.V; Indometacina [INN-Spanish]; Indometacine [INN-French]; Indometacinum [INN-Latin]; Indomethacin (USP); Indomethacin [USAN:BAN]; Novo-Methacin; Indochron E-R (TN); Indocin I.V.; Indocin-SR (TN); Indometacin (JP15/INN); Indomethacin & MAP-30; Indomethacin, Indochron E-R, Indocin-SR, Indocid, Indocin, Indomethacin
Therapeutic ClassAntiinflammatory Agents
Cross-matching ID
PubChem CID
3715
ChEBI ID
CHEMBL6
CAS Number
CAS 53-86-1
TTD Drug ID
D0R1RS
VARIDT Drug ID
DR00267
INTEDE Drug ID
DR0875
ACDINA Drug ID
D00329

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome 2.30 0.00e+0 113/158 (71.52%) MRPS16;RPS5;MRPL35;...
Mineral absorption 2.16 0.00e+0 48/60 (80%) STEAP1;HMOX1;TF;...
Retinol metabolism 2.03 0.00e+0 41/68 (60.29%) CYP3A5;CYP26B1;UGT2B17;...
Drug metabolism 2.00 0.00e+0 78/151 (51.66%) IMPDH2;GSTO1;CYP3A5;...
Homologous recombination 1.99 0.00e+0 35/41 (85.37%) RPA3;RAD54B;RAD51;...
Metabolism of xenobiotics by cytochrome P450 1.97 0.00e+0 49/77 (63.64%) CBR3;GSTO1;CYP3A5;...
Fanconi anemia pathway 1.92 3.94e-3 36/54 (66.67%) RPA3;RAD51;HES1;...
Spliceosome 1.90 6.89e-3 101/150 (67.33%) LSM5;PRPF4;LSM2;...
Non-homologous end-joining 1.89 7.65e-3 11/13 (84.62%) DNTT;NHEJ1;DCLRE1C;...
Ribosome biogenesis in eukaryotes 1.85 8.95e-3 52/108 (48.15%) RPP40;HEATR1;GNL3;...
Cell cycle 1.76 2.07e-2 110/124 (88.71%) PLK1;CDC20;CDC25B;...
DNA replication 1.75 1.89e-2 34/36 (94.44%) POLE2;RFC5;RPA3;...
RNA transport 1.71 2.65e-2 128/186 (68.82%) EIF5;NDC1;RPP40;...
Basal transcription factors 1.69 2.90e-2 37/45 (82.22%) MNAT1;TAF9B;GTF2H5;...
Nucleotide excision repair 1.67 3.12e-2 40/47 (85.11%) POLE2;RFC5;RPA3;...
Proximal tubule bicarbonate reclamation 1.67 3.06e-2 21/23 (91.3%) CA2;PCK1;GLUD1;...
Porphyrin and chlorophyll metabolism 1.65 3.32e-2 23/43 (53.49%) HMOX1;CPOX;UGT2B17;...
Pentose and glucuronate interconversions 1.64 3.63e-2 17/34 (50%) SORD;AKR1B10;UGT2B17;...
Folate biosynthesis 1.62 3.99e-2 23/26 (88.46%) GGH;AKR1B10;AKR1C3;...
Steroid hormone biosynthesis 1.62 3.82e-2 43/61 (70.49%) CYP3A5;UGT2B17;AKR1C3;...
IL-17 signaling pathway 1.60 4.33e-2 84/94 (89.36%) CXCL3;CXCL8;CXCL6;...
Human papillomavirus infection -1.82 2.17e-2 284/331 (85.8%) ITGB6;COL6A3;THBS3;...
Viral myocarditis -1.90 1.36e-2 53/60 (88.33%) ABL2;HLA-DQA1;ICAM1;...
Glycosaminoglycan degradation -2.03 0.00e+0 19/19 (100%) HPSE2;HGSNAT;ARSB;...
ECM-receptor interaction -2.07 0.00e+0 80/88 (90.91%) ITGB6;COL6A3;THBS3;...
Lysosome -2.36 0.00e+0 115/128 (89.84%) CTSW;CTSO;ARSB;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 15uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 100uM 24H, 48H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 100uM 24H, 48H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 10uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H