Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMSCR2H)

Drug Name
Cerdulatinib Drug Info
Synonyms PRT-062070; Syk + JAK multikinase inhibitor (NHL/CLL/RA), Portola Pharmaceuticals
Cross-matching ID
PubChem CID
44595079
ChEBI ID
CHEMBL4116008
CAS Number
CAS 1198300-79-6
TTD Drug ID
D0BI3N

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
PPAR signaling pathway 2.29 0.00e+0 66/74 (89.19%) HMGCS1;LPL;FABP1;...
Steroid biosynthesis 2.20 0.00e+0 19/20 (95%) SQLE;MSMO1;SC5D;...
Terpenoid backbone biosynthesis 2.02 0.00e+0 18/22 (81.82%) HMGCS1;IDI1;FDPS;...
Synthesis and degradation of ketone bodies 1.80 1.78e-2 9/10 (90%) HMGCS1;ACAT2;ACAT1
Biosynthesis of unsaturated fatty acids 1.73 3.55e-2 21/27 (77.78%) FADS2;FADS1;ELOVL6;...
Vibrio cholerae infection -1.67 3.37e-2 44/50 (88%) ARF1;ATP6V0B;ATP6V1F;...
Fc gamma R-mediated phagocytosis -1.67 3.40e-2 79/97 (81.44%) PIK3R1;GAB2;PLD2;...
Necroptosis -1.67 3.56e-2 113/159 (71.07%) TRADD;FTL;CHMP1B;...
Galactose metabolism -1.67 3.73e-2 26/31 (83.87%) B4GALT1;PGM1;AKR1B1;...
Th1 and Th2 cell differentiation -1.68 3.67e-2 80/92 (86.96%) IL4R;MAPK11;IL2RA;...
Viral carcinogenesis -1.69 3.66e-2 149/203 (73.4%) PKM;RBPJ;IKBKG;...
Mitophagy -1.69 3.87e-2 56/68 (82.35%) RAB7A;GABARAPL2;ULK1;...
Th17 cell differentiation -1.69 4.09e-2 95/107 (88.79%) CD3D;HLA-DQB1;HLA-DQA1;...
Lysosome -1.70 3.73e-2 115/128 (89.84%) ATP6V1H;CTSW;CTNS;...
Hepatitis C -1.71 3.65e-2 139/157 (88.54%) CLDN7;RIPK1;TLR3;...
Inflammatory bowel disease -1.72 3.46e-2 58/65 (89.23%) IL6;IL1A;TGFB2;...
Protein processing in endoplasmic reticulum -1.75 2.39e-2 127/171 (74.27%) PLAA;CRYAA;BCAP31;...
Asthma -1.76 2.28e-2 25/31 (80.65%) HLA-DOA;HLA-DPA1;CD40;...
Intestinal immune network for IgA production -1.78 1.69e-2 38/48 (79.17%) PIGR;TNFSF13;IL6;...
Herpes simplex virus 1 infection -1.86 7.46e-3 165/498 (33.13%) EIF2AK1;IL6;EIF2B1;...
Influenza A -1.92 4.14e-3 156/172 (90.7%) SLC25A5;JAK2;MAP2K2;...
Measles -1.94 4.66e-3 133/139 (95.68%) TRADD;TAB2;MX2;...
Graft-versus-host disease -1.98 1.78e-3 32/42 (76.19%) FASLG;IL6;IL1A;...
Epstein-Barr virus infection -2.00 2.07e-3 189/202 (93.56%) RBPJ;IKBKG;MAPK14;...
Collecting duct acid secretion -2.03 2.49e-3 22/27 (81.48%) ATP6V1A;ATP4B;ATP6V1B2;...
Type I diabetes mellitus -2.03 3.11e-3 38/43 (88.37%) FASLG;LTA;IL1A;...
Antigen processing and presentation -2.04 4.14e-3 60/78 (76.92%) HSPA4;HLA-DOA;PSME3;...
Autoimmune thyroid disease -2.06 6.21e-3 46/53 (86.79%) HLA-DOA;CTLA4;HLA-B;...
Allograft rejection -2.08 1.24e-2 32/38 (84.21%) HLA-DOA;HLA-B;HLA-DPA1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
K-562 CVCL_0004 Homo sapiens 0.01uM - 10uM 24H
Multiple myeloma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
KMS-34 CVCL_1333 Homo sapiens 0.01uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 24H
Lymph node
Burkitt lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BJAB CVCL_5711 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HBL-1 CVCL_4213 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly10 CVCL_8795 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly19 CVCL_8797 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly3 CVCL_8796 Homo sapiens 0.01uM - 10uM 24H
TMD8 CVCL_A440 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Mantle cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MINO CVCL_4965 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Peripheral blood
Acute B-lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NALM-6 CVCL_0092 Homo sapiens 0.01uM - 10uM 24H
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-MEL-5 CVCL_0527 Homo sapiens 0.01uM - 10uM 24H