Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMSE3I7)

Drug Name
Gemcitabine Drug Info
Synonyms
Gemcitabine hydrochloride; DDFC; DFdC; DFdCyd; Folfugem; GEO; Gamcitabine; GemLip; Gemcel; Gemcin; Gemcitabina; Gemcitabinum; Gemtro; Gemzar; Zefei; Gemcitabine HCl; Gemcitabine stereoisomer; LY 188011; LY188011; Gemcitabina [INN-Spanish]; Gemcitabinum [INN-Latin]; Gemzar (TN); Gemzar (hydrochloride); Inno-D07001; LY-188011; Gemcitabine (USAN/INN)
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
60750
ChEBI ID
CHEMBL175901
CAS Number
CAS 95058-81-4
TTD Drug ID
D03UVS
VARIDT Drug ID
DR00063
INTEDE Drug ID
DR0765

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
p53 signaling pathway 2.68 0.00e+0 63/73 (86.3%) CDKN1A;DDB2;GADD45A;...
Graft-versus-host disease 2.19 0.00e+0 32/42 (76.19%) FAS;HLA-B;HLA-C;...
Epstein-Barr virus infection 2.16 0.00e+0 189/202 (93.56%) CDKN1A;DDB2;GADD45A;...
Small cell lung cancer 2.16 0.00e+0 90/92 (97.83%) CDKN1A;DDB2;GADD45A;...
Mismatch repair 2.15 0.00e+0 22/23 (95.65%) PCNA;LIG1;RFC4;...
DNA replication 2.14 0.00e+0 34/36 (94.44%) PCNA;LIG1;MCM4;...
IL-17 signaling pathway 1.97 1.54e-3 84/94 (89.36%) S100A8;PTGS2;S100A7;...
Influenza A 1.97 1.35e-3 156/172 (90.7%) FAS;TNFRSF10B;MX1;...
TNF signaling pathway 1.96 1.20e-3 103/112 (91.96%) FAS;PTGS2;JUN;...
Pyrimidine metabolism 1.95 2.16e-3 40/56 (71.43%) RRM2;TYMS;PNP;...
Glutathione metabolism 1.94 1.97e-3 43/57 (75.44%) RRM2;GSTM3;CHAC1;...
NF-kappa B signaling pathway 1.94 1.80e-3 90/104 (86.54%) GADD45A;RELB;PTGS2;...
C-type lectin receptor signaling pathway 1.94 1.66e-3 93/104 (89.42%) RELB;PTGS2;IRF9;...
Allograft rejection 1.93 1.54e-3 32/38 (84.21%) FAS;HLA-B;HLA-C;...
Herpes simplex virus 1 infection 1.93 1.44e-3 165/498 (33.13%) FAS;HLA-B;TAP1;...
Nucleotide excision repair 1.93 2.03e-3 40/47 (85.11%) DDB2;PCNA;LIG1;...
Type I diabetes mellitus 1.89 3.18e-3 38/43 (88.37%) FAS;HLA-B;HLA-C;...
Caffeine metabolism 1.89 3.60e-3 5/6 (83.33%) NAT1
Melanoma 1.88 3.98e-3 68/72 (94.44%) CDKN1A;DDB2;GADD45A;...
Measles 1.87 3.78e-3 133/139 (95.68%) FAS;MX1;CCNE2;...
Drug metabolism 1.83 5.66e-3 78/151 (51.66%) RRM2;GSTM3;NAT1;...
Viral myocarditis 1.83 5.40e-3 53/60 (88.33%) HLA-B;CXADR;HLA-C;...
Kaposi sarcoma-associated herpesvirus infection 1.82 5.17e-3 172/193 (89.12%) CDKN1A;FAS;PTGS2;...
Apoptosis 1.80 8.11e-3 126/168 (75%) GADD45A;FAS;TNFRSF10B;...
NOD-like receptor signaling pathway 1.79 9.08e-3 145/181 (80.11%) IRF9;CXCL8;JUN;...
Basal cell carcinoma 1.75 1.33e-2 41/63 (65.08%) CDKN1A;DDB2;GADD45A;...
Viral carcinogenesis 1.75 1.32e-2 149/203 (73.4%) CDKN1A;PMAIP1;HLA-B;...
Fanconi anemia pathway 1.73 1.66e-2 36/54 (66.67%) FANCI;BRCA1;RPA2;...
Glioma 1.73 1.60e-2 67/75 (89.33%) CDKN1A;DDB2;GADD45A;...
Hepatitis C 1.73 1.69e-2 139/157 (88.54%) CDKN1A;FAS;MX1;...
Ribosome -1.74 3.14e-2 113/158 (71.52%) RPL13;RPS26;RPL17;...
Ribosome biogenesis in eukaryotes -1.74 3.60e-2 52/108 (48.15%) NXF3;PWP2;TCOF1;...
Progesterone-mediated oocyte maturation -1.78 2.14e-2 75/100 (75%) RAF1;MAPK14;ANAPC1;...
Aminoacyl-tRNA biosynthesis -1.90 2.85e-3 15/66 (22.73%) CARS2;NARS2;QRSL1;...
RNA transport -2.07 0.00e+0 128/186 (68.82%) ACIN1;PNN;EIF2B5;...
Spliceosome -2.50 0.00e+0 101/150 (67.33%) SART1;SF3B2;PPIH;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 0.08uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.002uM - 12uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 0.08uM 6H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 0.08uM 6H
MDST8 CVCL_1400 Homo sapiens 0.08uM 6H
NCI-H508 CVCL_1561 Homo sapiens 0.08uM 6H
SNU-1040 CVCL_5001 Homo sapiens 0.08uM 6H
SNU-C4 CVCL_5008 Homo sapiens 0.08uM 6H
SNU-C5 CVCL_5009 Homo sapiens 0.08uM 6H
SW480 CVCL_0546 Homo sapiens 0.08uM 6H
SW620 CVCL_0547 Homo sapiens 0.08uM 6H
SW948 CVCL_0550 Homo sapiens 0.08uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 0.08uM 6H
HT115 CVCL_1294 Homo sapiens 0.08uM 6H
RKO CVCL_0504 Homo sapiens 0.08uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 0.08uM 6H
SNG-M CVCL_1707 Homo sapiens 0.08uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 0.08uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 12.5uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.002uM - 12uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 0.08uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 0.08uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 0.08uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 0.08uM 6H
T3M-10 CVCL_1729 Homo sapiens 0.08uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 0.08uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 0.08uM 6H
HCC515 CVCL_5134 Homo sapiens 0.002uM - 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 0.08uM 6H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 0.08uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 0.08uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 0.08uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 0.08uM 6H
OV7 CVCL_1623 Homo sapiens 0.08uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 0.08uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 0.08uM 6H
RMUG-S CVCL_1666 Homo sapiens 0.08uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 0.08uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 0.08uM 6H
PL-21 CVCL_2161 Homo sapiens 0.08uM 6H
SKM-1 CVCL_0010 Homo sapiens 0.08uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 0.08uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.002uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 0.08uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 0.08uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 0.08uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 0.08uM 6H