Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMSEIUP)

• Drug Name: 2-iodo-melatonin Drug Info
• Synonyms: 2-Iodomelatonin; 93515-00-5; n-[2-(2-iodo-5-methoxy-1h-indol-3-yl)ethyl]acetamide; CHEMBL289233; N-(2-(2-Iodo-5-methoxy-1H-indol-3-yl)ethyl)acetamide; acetamide,n-[2-(2-iodo-5-methoxy-1h-indol-3-yl)ethyl]-; Acetamide, N-(2-(2-iodo-5-methoxy-1H-indol-3-yl)ethyl)-, (3beta)-; Acetamide, N-(2-(2-iodo-5-methoxy-1H-indol-3-yl)ethyl)-; SR-01000075935; 2-I-MLT; Melatonin,2-Iodo; ML2; Tocris-0737; Lopac-I-1899; AC1L3GZ8; AC1Q5P6Z; Lopac0_000610; SCHEMBL163451; GTPL1343; BDBM29611; CTK8F4316; DTXSID30239462; 2-iodomelatonin; IODOMELATONIN
• Cross-matching ID:
  PubChem CID: 115348
  ChEBI ID: CHEMBL289233
  CAS Number: CAS 93515-00-5
  TTD Drug ID: D0H6YF

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Malaria	-1.74	4.41e-2	44/50 (88%)	CD81;VCAM1;CD40;...
Inflammatory bowel disease	-1.81	2.82e-2	58/65 (89.23%)	RELA;STAT3;IL6;...
Intestinal immune network for IgA production	-1.82	3.30e-2	38/48 (79.17%)	CD40;IL6;CXCR4;...
Systemic lupus erythematosus	-1.87	8.81e-3	45/135 (33.33%)	C6;C5;CD40;...
Rheumatoid arthritis	-1.94	4.41e-3	78/93 (83.87%)	MMP1;CXCL3;CSF1;...
Staphylococcus aureus infection	-2.02	8.81e-3	72/95 (75.79%)	KRT10;CFD;HLA-DMB;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲