Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMSEVBH)

Drug Name
Lersivirine Drug Info
Synonyms cc-718; Lersivirine (UK-453061)
Cross-matching ID
PubChem CID
16739244
CAS Number
CAS 473921-12-9
TTD Drug ID
D08SSP
INTEDE Drug ID
DR1825

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Systemic lupus erythematosus 1.91 1.25e-2 45/135 (33.33%) C1QA;HLA-DQB1;C1QB;...
DNA replication 1.90 9.40e-3 34/36 (94.44%) PCNA;FEN1;MCM6;...
Graft-versus-host disease 1.87 1.04e-2 32/42 (76.19%) HLA-DQB1;HLA-DPA1;HLA-DRA;...
Allograft rejection 1.85 7.83e-3 32/38 (84.21%) HLA-DQB1;HLA-DPA1;HLA-DRA;...
Viral myocarditis 1.84 7.52e-3 53/60 (88.33%) HLA-DQB1;ACTB;HLA-DPA1;...
Tyrosine metabolism -1.76 4.71e-2 30/36 (83.33%) TYR;ALDH3B1;ALDH3A1;...
NOD-like receptor signaling pathway -1.80 3.56e-2 145/181 (80.11%) CYBB;TRIP6;BIRC3;...
Epithelial cell signaling in Helicobacter pylori infect... -1.80 3.69e-2 62/70 (88.57%) ATP6V1G1;PTPN11;SRC;...
Kaposi sarcoma-associated herpesvirus infection -1.86 2.21e-2 172/193 (89.12%) MAPK3;IFNB1;MAPK14;...
Bladder cancer -1.91 2.08e-2 40/41 (97.56%) ERBB2;FGFR3;DAPK1;...
Mineral absorption -1.98 1.38e-2 48/60 (80%) ATOX1;ATP2B1;TF;...
TNF signaling pathway -2.00 1.38e-2 103/112 (91.96%) BIRC3;LIF;MAPK3;...
IL-17 signaling pathway -2.14 0.00e+0 84/94 (89.36%) HSP90AA1;CEBPB;S100A7;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 2.22uM 24H