Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMSFQ8I)

• Drug Name: Meclocycline Drug Info
• Synonyms: Meclociclina; Meclocyclinum; Meclosorb; Samil; Meclociclina [Italian]; GS 2989; GS-2989; Meclociclina [INN-Spanish]; Meclocycline(USAN); Meclocyclinum [INN-Latin]; Meclocycline (USAN/INN); Meclocycline [USAN:INN:BAN]; (2E,4S,4aR,5S,5aR,12aS)-2-[amino(hydroxy)methylidene]-7-chloro-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methylidene-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione; (2E,4aR,5S,5aS,12aS)-2-[amino(hydroxy)methylidene]-7-chloro-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methylidene-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione; (2Z)-2-[amino(hydroxy)methylidene]-7-chloro-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methylidene-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione; (2Z,4S,4aR,5S,5aR,12aS)-2-[amino(hydroxy)methylidene]-7-chloro-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methylidene-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione; 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-, [4S-(4.alpha.,4a.alpha.,5.alpha.,5a.alpha.,12a.alpha.)]-(9CI); 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-, [4S-(4.alpha.,4aal; 2-[amino(hydroxy)methylidene]-7-chloro-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methylidene-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione; 7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-2-naphthacenecarboxamide; 7-Chloro-6-methylene-5-oxytetracycline; 7-Cloro-6-metilene-5-ossitetraciclina; 7-Cloro-6-metilene-5-ossitetraciclina [Italian]; 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-2-naphthacene carboxamide
• Therapeutic Class: Antibiotics
• Cross-matching ID:
  PubChem CID: 54676539
  ChEBI ID: CHEMBL135772
  CAS Number: CAS 2013-58-3
  TTD Drug ID: D07JHH

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Galactose metabolism	-1.69	4.68e-2	26/31 (83.87%)	UGP2;PFKP;HK1;...
Ferroptosis	-1.72	3.58e-2	36/41 (87.8%)	PRNP;GCLM;STEAP3;...
Autophagy	-1.75	2.70e-2	113/169 (66.86%)	INS;MRAS;ATG5;...
Antigen processing and presentation	-1.77	2.30e-2	60/78 (76.92%)	HSPA4;PSME3;HLA-A;...
Bacterial invasion of epithelial cells	-1.85	2.28e-3	59/77 (76.62%)	ITGB1;CD2AP;CTNNA1;...
Lysosome	-1.89	1.25e-3	115/128 (89.84%)	AP3M2;CTSW;ATP6V0B;...
Vibrio cholerae infection	-1.89	1.39e-3	44/50 (88%)	ATP6V0D1;KDELR2;SEC61B;...
Sphingolipid metabolism	-1.91	1.57e-3	32/49 (65.31%)	KDSR;SMPD1;ARSA;...
Systemic lupus erythematosus	-1.91	1.79e-3	45/135 (33.33%)	HLA-DPA1;C5;HLA-DOA;...
Allograft rejection	-1.99	0.00e+0	32/38 (84.21%)	HLA-DMB;PRF1;HLA-G;...
Asthma	-2.00	0.00e+0	25/31 (80.65%)	IL4;CCL11;IL9;...
Collecting duct acid secretion	-2.03	0.00e+0	22/27 (81.48%)	ATP4B;CA2;ATP4A;...
Viral myocarditis	-2.12	0.00e+0	53/60 (88.33%)	ABL2;HLA-DMB;PRF1;...
Autoimmune thyroid disease	-2.12	0.00e+0	46/53 (86.79%)	IFNA17;HLA-DMB;IFNA21;...
Complement and coagulation cascades	-2.25	0.00e+0	76/85 (89.41%)	F3;C5;CD46;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H	Hide ▲

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H	Show ▼