Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMSHIQA)

Drug Name
CID755673 Drug Info
Synonyms
CID755673; 521937-07-5; CID 755673; cid-755673; MLS000043346; 7-Hydroxy-2,3,4,5-tetrahydro-1H-benzofuro[2,3-c]azepin-1-one; 7-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c]azepin-1-one; SMR000019965; 7-hydroxy-2,3,4,5-tetrahydro-[1]benzofuro[2,3-c]azepin-1-one; 2,3,4,5-Tetrahydro-7-hydroxy-1H-benzofuro[2,3-c]azepin-1-one; 3-Hydroxy-5,6,7,8-tetrahydro-10-oxa-8-aza-benzo[a]azulen-9-one; AC1LFLHI; SCHEMBL9904268; cid_755673; REGID_for_CID_755673; CHEMBL1450770; BDBM32334; CTK4J5567; CHEBI:92059; KS-00001CWT; EX-A393
Cross-matching ID
PubChem CID
755673
ChEBI ID
CHEMBL1450770
CAS Number
CAS 521937-07-5
TTD Drug ID
D0MC3K

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.27 0.00e+0 34/36 (94.44%) RPA3;RFC5;POLD2;...
Ribosome 2.09 4.26e-3 113/158 (71.52%) RPS4Y1;RPS5;MRPL28;...
Fanconi anemia pathway 1.87 3.69e-2 36/54 (66.67%) RPA3;FANCA;BRCA1;...
Pyrimidine metabolism 1.86 2.98e-2 40/56 (71.43%) CTPS1;ENPP1;DCTPP1;...
Cell cycle 1.82 2.90e-2 110/124 (88.71%) MAD2L1;CCNA2;CCNB2;...
Nucleotide excision repair 1.77 3.26e-2 40/47 (85.11%) RPA3;RFC5;POLD2;...
Type I diabetes mellitus 1.77 2.80e-2 38/43 (88.37%) CPE;HLA-F;IL1B;...
Homologous recombination 1.76 2.66e-2 35/41 (85.37%) RPA3;POLD2;RBBP8;...
RNA transport 1.76 2.46e-2 128/186 (68.82%) EIF3G;NUP107;EIF3D;...
Proteasome 1.74 2.38e-2 44/46 (95.65%) PSMB8;PSMC3;PSMB9;...
Mismatch repair 1.73 2.17e-2 22/23 (95.65%) RPA3;RFC5;POLD2;...
Ribosome biogenesis in eukaryotes 1.71 2.13e-2 52/108 (48.15%) EIF6;NHP2;RPP30;...
RNA degradation 1.68 2.95e-2 53/79 (67.09%) EXOSC7;PABPC4;CNOT2;...
Allograft rejection 1.66 3.16e-2 32/38 (84.21%) HLA-F;HLA-E;CD40;...
Cytosolic DNA-sensing pathway 1.62 4.88e-2 52/63 (82.54%) CXCL10;IL1B;CCL4;...
Ferroptosis -2.23 0.00e+0 36/41 (87.8%) SLC11A2;CYBB;PRNP;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 0.04uM - 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H