Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMSHPW8)

• Drug Name: Tolterodine Drug Info
• Synonyms: Tolterodina; Tolterodinum; Detrol (TN); Detrusitol (TN); Kabi-2234; 2-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-methylphenol; 2-[(1R)-3-[di(propan-2-yl)amino]-1-phenylpropyl]-4-methylphenol; 2-[3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-methylphenol; 2-{(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl}-4-methylphenol
• Therapeutic Class: Antispasmodics
• Cross-matching ID:
  PubChem CID: 443879
  ChEBI ID: CHEMBL1382
  CAS Number: CAS 124937-51-5
  TTD Drug ID: D0BZ7W
  INTEDE Drug ID: DR1616
  ACDINA Drug ID: D00183

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Steroid biosynthesis	1.97	2.41e-2	19/20 (95%)	TM7SF2;HSD17B7;CYP51A1;...
Inositol phosphate metabolism	-1.68	4.63e-2	66/73 (90.41%)	PIK3CG;MTMR1;INPP5D;...
Carbohydrate digestion and absorption	-1.68	4.45e-2	37/47 (78.72%)	HK3;PIK3CA;ATP1A2;...
Osteoclast differentiation	-1.70	3.81e-2	117/127 (92.13%)	SYK;FCGR3B;MAPK9;...
Histidine metabolism	-1.70	4.03e-2	16/22 (72.73%)	CNDP2;ALDH3A1;MAOA;...
Epithelial cell signaling in Helicobacter pylori infect...	-1.72	3.71e-2	62/70 (88.57%)	MAPK10;ATP6V1H;ATP6V1E1;...
TNF signaling pathway	-1.73	3.50e-2	103/112 (91.96%)	TNFRSF1B;CXCL2;TNF;...
Neutrophil extracellular trap formation	-1.75	3.35e-2	101/189 (53.44%)	SYK;FCGR3B;MPO;...
NF-kappa B signaling pathway	-1.76	3.25e-2	90/104 (86.54%)	GADD45B;CXCL2;TNF;...
Collecting duct acid secretion	-1.77	3.24e-2	22/27 (81.48%)	ATP4A;SLC12A7;ATP6V0D1;...
Mineral absorption	-1.78	3.32e-2	48/60 (80%)	ATP1A2;ATP1B1;HMOX1;...
Staphylococcus aureus infection	-1.78	3.43e-2	72/95 (75.79%)	FCGR2A;ITGAM;C5AR1;...
Aldosterone-regulated sodium reabsorption	-1.82	2.54e-2	34/37 (91.89%)	PIK3CA;ATP1A2;ATP1B1;...
Pathogenic Escherichia coli infection	-1.83	2.71e-2	152/197 (77.16%)	SEC24B;CASP8;TNFSF10;...
NOD-like receptor signaling pathway	-1.87	1.96e-2	145/181 (80.11%)	MAPK9;VDAC2;CASP8;...
Salmonella infection	-1.89	2.29e-2	198/249 (79.52%)	AHNAK2;KPNA4;PIK3CA;...
Shigellosis	-1.93	1.60e-2	180/246 (73.17%)	ITPR1;PIK3CA;IKBKB;...
Pertussis	-1.97	5.71e-3	64/76 (84.21%)	CALML4;TNF;CASP3;...
Nitrogen metabolism	-1.99	3.81e-3	16/17 (94.12%)	CA9;GLUL;CA2;...
Legionellosis	-2.03	5.71e-3	51/57 (89.47%)	CXCL2;TNF;CASP3;...
IL-17 signaling pathway	-2.21	0.00e+0	84/94 (89.36%)	MMP1;CXCL2;TNF;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H	Hide ▲

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H	Show ▼