Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMSIVND)

• Drug Name: Hydroxychloroquine Drug Info
• Synonyms: Hidroxicloroquina; Hidroxicloroquina [INN-Spanish]; Hydroxychlorochin; Gen-Hydroxychloroquine 200mg Tablets; HCQ; Hydroxychloroguine; Hydroxychloroquine (INN);Hydroxychloroquine [INN:BAN]; Hydroxychloroquine Sulfate (1:1) Salt; Hydroxychloroquinum; Hydroxychloroquinum [INN-Latin]; Idrossiclorochina; Idrossiclorochina [DCIT]; Oxichlorochinum; Oxichloroquine; Oxychlorochin; Oxychloroquine; Plaquenil (TN); Polirreumin; Polirreumin (TN); Quensyl; WIN 1258
• Therapeutic Class: Antimalarials
• Cross-matching ID:
  PubChem CID: 3652
  ChEBI ID: CHEMBL1535
  CAS Number: CAS 118-42-3
  TTD Drug ID: D0OJ4L
  VARIDT Drug ID: DR00449
  INTEDE Drug ID: DR0837
  ACDINA Drug ID: D00316

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Spliceosome	1.98	0.00e+0	101/150 (67.33%)	SRSF7;SNRPD1;SRSF1;...
RNA transport	1.92	4.24e-3	128/186 (68.82%)	RPP38;RAN;EIF4G1;...
Aminoacyl-tRNA biosynthesis	1.84	1.70e-2	15/66 (22.73%)	QRSL1;WARS2;NARS2;...
Neutrophil extracellular trap formation	1.82	1.48e-2	101/189 (53.44%)	MPO;AZU1;ELANE;...
Ribosome biogenesis in eukaryotes	1.79	2.03e-2	52/108 (48.15%)	RPP38;RAN;GTPBP4;...
DNA replication	1.77	2.12e-2	34/36 (94.44%)	FEN1;PCNA;MCM7;...
Terpenoid backbone biosynthesis	1.71	4.72e-2	18/22 (81.82%)	PDSS1;ACAT2;IDI1;...
Autophagy	-1.67	4.80e-2	113/169 (66.86%)	ULK1;IGBP1;ERN1;...
Steroid hormone biosynthesis	-1.71	3.84e-2	43/61 (70.49%)	CYP11A1;UGT2B15;CYP17A1;...
Graft-versus-host disease	-1.71	4.16e-2	32/42 (76.19%)	KLRD1;HLA-DOB;IFNG;...
Protein processing in endoplasmic reticulum	-1.72	4.32e-2	127/171 (74.27%)	SSR2;CANX;EDEM2;...
Glycine, serine and threonine metabolism	-1.72	4.29e-2	31/40 (77.5%)	ALAS2;BPGM;GCAT;...
Mineral absorption	-1.73	4.25e-2	48/60 (80%)	ATP7A;SLC30A1;MT1E;...
Regulation of lipolysis in adipocytes	-1.77	3.04e-2	52/55 (94.55%)	ADCY1;NPY1R;AKT3;...
Ovarian steroidogenesis	-1.78	3.48e-2	41/51 (80.39%)	ADCY7;CYP1A1;LHCGR;...
MicroRNAs in cancer	-1.80	3.09e-2	146/310 (47.1%)	MARCKS;SOX4;NOTCH2;...
Vibrio cholerae infection	-1.80	3.71e-2	44/50 (88%)	ATP6V1F;ACTB;ATP6AP1;...
Collecting duct acid secretion	-1.83	3.77e-2	22/27 (81.48%)	SLC4A1;ATP6V1G1;ATP6V0E2;...
SNARE interactions in vesicular transport	-1.88	1.55e-2	19/33 (57.58%)	SNAP23;SNAP29;STX8;...
Mitophagy	-2.01	0.00e+0	56/68 (82.35%)	TFE3;CSNK2A2;OPTN;...
Lysosome	-2.07	0.00e+0	115/128 (89.84%)	GGA2;PLA2G15;FUCA1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow

Chronic myeloid leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
K-562	CVCL_0004	Homo sapiens	0.01uM - 10uM	4H, 24H	Hide ▲

Multiple myeloma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
KMS-34	CVCL_1333	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Show ▼

Fibroblast

Nasopharyngeal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
FIBRNPC	CVCL_UK07	Homo sapiens	10uM	6H, 24H	Show ▼

Lymph node

Burkitt lymphoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
BJAB	CVCL_5711	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Diffuse large B-cell lymphoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HBL-1	CVCL_4213	Homo sapiens	0.01uM - 10uM	4H, 24H	Show ▼
OCI-Ly19	CVCL_8797	Homo sapiens	0.01uM - 10uM	4H, 24H	Show ▼
OCI-Ly3	CVCL_8796	Homo sapiens	0.01uM - 10uM	4H, 24H	Show ▼
TMD8	CVCL_A440	Homo sapiens	0.01uM - 10uM	4H, 24H	Show ▼

Mantle cell lymphoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MINO	CVCL_4965	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute B-lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
NALM-6	CVCL_0092	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
SK-MEL-5	CVCL_0527	Homo sapiens	0.01uM - 10uM	24H	Show ▼