Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMSNVKP)

Drug Name
CP 93129 Drug Info
Synonyms CP-93129; CP93129; CP-93,129
Cross-matching ID
PubChem CID
124007
ChEBI ID
CHEMBL304008
CAS Number
CAS 127792-75-0
TTD Drug ID
D00FHZ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Morphine addiction 1.94 1.14e-2 80/91 (87.91%) GNAS;PRKACB;PRKCB;...
Cytosolic DNA-sensing pathway 1.87 2.29e-2 52/63 (82.54%) CXCL10;CCL4;PYCARD;...
Progesterone-mediated oocyte maturation 1.87 1.53e-2 75/100 (75%) STK10;PRKACB;CCNB1;...
Retrograde endocannabinoid signaling 1.87 1.14e-2 118/148 (79.73%) PRKACB;PRKCB;MGLL;...
Regulation of lipolysis in adipocytes 1.75 4.58e-2 52/55 (94.55%) GNAS;PRKACB;FABP4;...
Inflammatory mediator regulation of TRP channels 1.73 4.90e-2 82/98 (83.67%) GNAS;PRKACB;MAP2K6;...
Human immunodeficiency virus 1 infection 1.72 4.86e-2 189/212 (89.15%) MAP2K6;CCNB1;PRKCB;...
Collecting duct acid secretion -1.88 3.35e-2 22/27 (81.48%) ATP6V1B1;SLC12A7;ATP6V0A2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H