Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMSOUI0)

Drug Name
AG 9 Drug Info
Synonyms tyrphostin 1; tyrphostin A1; AG9; AG-9
Cross-matching ID
PubChem CID
2063
ChEBI ID
CHEMBL77456
CAS Number
CAS 2826-26-8
TTD Drug ID
D0H3UI

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Spliceosome 2.15 0.00e+0 101/150 (67.33%) HSPA8;LSM5;PUF60;...
DNA replication 1.95 1.65e-2 34/36 (94.44%) PCNA;MCM6;POLE3;...
RNA transport 1.80 3.95e-2 128/186 (68.82%) EIF1AY;SRRM1;NUP85;...
Cell cycle 1.79 3.29e-2 110/124 (88.71%) CHEK1;CCND2;PLK1;...
Homologous recombination 1.79 2.63e-2 35/41 (85.37%) BRCA1;BARD1;RAD54B;...
Proteasome 1.76 2.96e-2 44/46 (95.65%) PSMD11;PSMD4;PSMC6;...
RNA degradation 1.73 3.95e-2 53/79 (67.09%) LSM5;BTG2;MPHOSPH6;...
Ribosome biogenesis in eukaryotes 1.72 3.62e-2 52/108 (48.15%) HEATR1;POP1;RPP40;...
Fanconi anemia pathway 1.69 4.61e-2 36/54 (66.67%) BRCA1;FANCI;RAD51;...
Mitophagy -1.66 3.40e-2 56/68 (82.35%) RAB7A;BNIP3L;NBR1;...
Synaptic vesicle cycle -1.68 2.92e-2 63/78 (80.77%) SLC17A7;ATP6V1A;ATP6V0E1;...
Ascorbate and aldarate metabolism -1.68 3.03e-2 15/30 (50%) AKR1A1;UGDH;GUSB;...
beta-Alanine metabolism -1.69 2.99e-2 25/30 (83.33%) ALDH7A1;GAD1;ALDH6A1;...
Malaria -1.69 3.11e-2 44/50 (88%) ACKR1;MET;GYPA;...
Glutathione metabolism -1.70 3.07e-2 43/57 (75.44%) GSTT1;IDH1;GSTA4;...
Carbohydrate digestion and absorption -1.73 1.77e-2 37/47 (78.72%) HK2;AKT1;PLCB4;...
Selenocompound metabolism -1.74 1.44e-2 11/17 (64.71%) KYAT1;KYAT3;TXNRD1;...
Pyruvate metabolism -1.74 1.50e-2 41/47 (87.23%) PC;ALDH7A1;ADH6;...
Taurine and hypotaurine metabolism -1.77 1.07e-2 8/11 (72.73%) BAAT;ADO;GGT5;...
Glucagon signaling pathway -1.78 1.06e-2 89/107 (83.18%) CREB3L1;PPP4R3B;GCGR;...
African trypanosomiasis -1.78 1.05e-2 32/37 (86.49%) VCAM1;FASLG;PLCB2;...
Fat digestion and absorption -1.78 1.03e-2 35/43 (81.4%) NPC1L1;LIPF;ABCG5;...
Mineral absorption -1.82 8.57e-3 48/60 (80%) ATOX1;VDR;SLC26A6;...
Arachidonic acid metabolism -1.83 9.10e-3 48/61 (78.69%) PLA2G12A;PLA2G6;TBXAS1;...
Synthesis and degradation of ketone bodies -1.84 7.06e-3 9/10 (90%) HMGCS2;OXCT2;BDH2;...
Tryptophan metabolism -1.84 7.56e-3 35/42 (83.33%) IDO1;ALDH7A1;DHTKD1;...
Retinol metabolism -1.86 7.13e-3 41/68 (60.29%) ADH7;RDH16;HSD17B6;...
Fatty acid degradation -1.90 3.31e-3 40/43 (93.02%) ACSL6;ADH7;ACADS;...
Arginine and proline metabolism -1.91 3.61e-3 39/50 (78%) P4HA2;P4HA1;GOT2;...
Protein digestion and absorption -1.92 3.97e-3 78/103 (75.73%) COL8A2;XPNPEP2;ELN;...
Ferroptosis -1.97 2.94e-3 36/41 (87.8%) SLC11A2;ATG7;PRNP;...
Glycine, serine and threonine metabolism -2.01 1.65e-3 31/40 (77.5%) AMT;ALDH7A1;PSPH;...
Steroid biosynthesis -2.03 0.00e+0 19/20 (95%) LSS;CYP27B1;NSDHL;...
Steroid hormone biosynthesis -2.05 0.00e+0 43/61 (70.49%) DHRS11;UGT2B4;HSD11B2;...
Glycolysis / Gluconeogenesis -2.05 0.00e+0 56/67 (83.58%) ADH7;PDHA1;GAPDHS;...
Other glycan degradation -2.07 0.00e+0 13/18 (72.22%) MAN2B2;FUCA1;GLB1;...
Alanine, aspartate and glutamate metabolism -2.11 0.00e+0 27/37 (72.97%) GLUL;GPT;GLUD2;...
Metabolism of xenobiotics by cytochrome P450 -2.14 0.00e+0 49/77 (63.64%) CYP2F1;UGT2B4;GSTT1;...
Arginine biosynthesis -2.33 0.00e+0 17/22 (77.27%) GLUL;GPT;GLUD2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 10uM 6H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 10uM 6H
MDST8 CVCL_1400 Homo sapiens 10uM 6H
NCI-H508 CVCL_1561 Homo sapiens 10uM 6H
SNU-1040 CVCL_5001 Homo sapiens 10uM 6H
SNU-C4 CVCL_5008 Homo sapiens 10uM 6H
SNU-C5 CVCL_5009 Homo sapiens 10uM 6H
SW480 CVCL_0546 Homo sapiens 10uM 6H
SW620 CVCL_0547 Homo sapiens 10uM 6H
SW948 CVCL_0550 Homo sapiens 10uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 10uM 6H
HT115 CVCL_1294 Homo sapiens 10uM 6H
RKO CVCL_0504 Homo sapiens 10uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 10uM 6H
SNG-M CVCL_1707 Homo sapiens 10uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 10uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 10uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 10uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 10uM 6H
T3M-10 CVCL_1729 Homo sapiens 10uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 10uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 10uM 6H
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 10uM 6H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 10uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 10uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 10uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 10uM 6H
OV7 CVCL_1623 Homo sapiens 10uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 10uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 10uM 6H
RMUG-S CVCL_1666 Homo sapiens 10uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 10uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 10uM 6H
PL-21 CVCL_2161 Homo sapiens 10uM 6H
SKM-1 CVCL_0010 Homo sapiens 10uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 10uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 10uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 10uM 6H