Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMSP4JX)

Drug Name
Cetraxate Drug Info
Synonyms Neuer; NeuerCap; NeuerS; Cetraxate hydrochloride; DV-1006
Cross-matching ID
PubChem CID
2680
ChEBI ID
CHEMBL17340
CAS Number
CAS 34675-84-8
TTD Drug ID
D0V9ZG

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Inflammatory bowel disease -1.66 4.62e-2 58/65 (89.23%) TGFB1;STAT1;HLA-DRB1;...
Malaria -1.68 4.22e-2 44/50 (88%) ITGB2;TGFB2;KLRB1;...
Leishmaniasis -1.68 4.50e-2 67/77 (87.01%) NCF4;NFKBIA;TGFB1;...
Viral protein interaction with cytokine and cytokine re... -1.69 4.66e-2 84/100 (84%) CCR2;CCR7;CCL11;...
Pertussis -1.71 4.00e-2 64/76 (84.21%) CASP1;ITGB2;GNAI3;...
Oxidative phosphorylation -1.74 2.86e-2 93/133 (69.92%) ATP5MF;COX8A;COX5B;...
Mucin type O-glycan biosynthesis -1.74 2.82e-2 20/36 (55.56%) C1GALT1C1;ST6GALNAC2;GALNT10;...
Lysosome -1.76 2.66e-2 115/128 (89.84%) GALC;CTSH;ENTPD4;...
Cell adhesion molecules -1.81 1.84e-2 118/148 (79.73%) L1CAM;CADM1;MADCAM1;...
Proximal tubule bicarbonate reclamation -1.84 9.68e-3 21/23 (91.3%) ATP1B1;ATP1B2;CA2;...
Toxoplasmosis -1.85 7.90e-3 103/112 (91.96%) NFKBIA;LDLR;TNFRSF1A;...
Phagosome -1.90 3.69e-3 118/152 (77.63%) LAMP1;ITGB2;HLA-DRB1;...
Renin secretion -1.93 0.00e+0 61/69 (88.41%) PRKACB;ITPR3;CLCA2;...
Steroid biosynthesis -2.00 0.00e+0 19/20 (95%) FDFT1;LIPA;SOAT1;...
Complement and coagulation cascades -2.10 0.00e+0 76/85 (89.41%) ITGB2;SERPINE1;A2M;...
Systemic lupus erythematosus -2.15 0.00e+0 45/135 (33.33%) HLA-DRB1;HLA-DQB1;CD86;...
Staphylococcus aureus infection -2.24 0.00e+0 72/95 (75.79%) ITGB2;HLA-DRB1;HLA-DQB1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H