Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMSPDZU)

Drug Name
Melperone Drug Info
Synonyms
MELPERONE; 3575-80-2; melperon; Methylperone; Metylperonum; 1-(4-fluorophenyl)-4-(4-methylpiperidin-1-yl)butan-1-one; FLUBUPERONE; Bunil; Metylperon; Buronil; Melperonum [INN-Latin]; Melperona [INN-Spanish]; UNII-J8WA3K39B7; Melperone [INN:BAN:DCF]; C16H22FNO; 4'-Fluoro-4-(4-methylpiperidino)butyrophenone; J8WA3K39B7; DKMFBWQBDIGMHM-UHFFFAOYSA-N; NCGC00167744-01; 1-(4-Fluorophenyl)-4-(4-methyl-1-piperidinyl)-1-butanone; 4'-Fluor-4-(4-methylpiperidino)butyrophenon; DSSTox_CID_3298; FG 5111; DSSTox_RID_76964; DSSTox_GSID_23298
Cross-matching ID
PubChem CID
15387
ChEBI ID
CHEMBL1531134
CAS Number
CAS 3575-80-2
TTD Drug ID
D05RUM

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Tryptophan metabolism -1.74 3.47e-2 35/42 (83.33%) ACAT2;KYAT3;MAOB;...
Valine, leucine and isoleucine degradation -1.74 3.90e-2 42/48 (87.5%) MCCC1;ECHS1;ACAD8;...
Pertussis -1.77 3.30e-2 64/76 (84.21%) C1S;TNF;IRF3;...
Primary immunodeficiency -1.81 1.73e-2 33/38 (86.84%) ICOS;CD8A;ZAP70;...
Ferroptosis -1.82 2.08e-2 36/41 (87.8%) CYBB;ACSL4;LPCAT3;...
African trypanosomiasis -1.88 5.78e-3 32/37 (86.49%) TNF;NPPA;FASLG;...
Steroid hormone biosynthesis -1.88 7.70e-3 43/61 (70.49%) CYP1A1;CYP3A7;CYP2E1;...
Steroid biosynthesis -2.04 0.00e+0 19/20 (95%) LSS;CYP27B1;NSDHL;...
Complement and coagulation cascades -2.26 0.00e+0 76/85 (89.41%) SERPINE1;CFHR2;FGB;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H