Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMSPJG2)

• Drug Name: Ropivacaine Drug Info
• Synonyms: Naropin; ROPIVACAINE HCl; Ropivacaine hydrochloride; Ropivacaine monohydrochloride; Naropin (TN); Ropivacaine monohydrochloride, (S)-isomer; (2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide; (2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride
• Therapeutic Class: Anesthetics
• Cross-matching ID:
  PubChem CID: 175805
  ChEBI ID: CHEMBL1077896
  CAS Number: CAS 84057-95-4
  TTD Drug ID: D09RHQ
  INTEDE Drug ID: DR1442

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Bile secretion	1.91	4.02e-2	68/90 (75.56%)	ADCY1;FXYD2;ABCC3;...
Starch and sucrose metabolism	-1.72	3.53e-2	25/36 (69.44%)	G6PC3;PYGM;GBE1;...
Phagosome	-1.72	3.78e-2	118/152 (77.63%)	TLR6;NCF4;CYBB;...
Amino sugar and nucleotide sugar metabolism	-1.72	4.20e-2	38/48 (79.17%)	NANS;MPI;GALE;...
Hematopoietic cell lineage	-1.73	4.23e-2	90/99 (90.91%)	IL1B;IL9R;GP9;...
Allograft rejection	-1.80	2.27e-2	32/38 (84.21%)	HLA-DMB;CD40;FASLG;...
Ribosome biogenesis in eukaryotes	-1.81	1.82e-2	52/108 (48.15%)	POP5;RIOK2;SNU13;...
Graft-versus-host disease	-1.86	1.19e-2	32/42 (76.19%)	FASLG;IFNG;KIR2DL1;...
Autoimmune thyroid disease	-1.93	9.95e-3	46/53 (86.79%)	HLA-DMB;CD40;IFNA21;...
Type I diabetes mellitus	-1.96	6.63e-3	38/43 (88.37%)	FASLG;IFNG;IL1B;...
Primary immunodeficiency	-2.02	9.95e-3	33/38 (86.84%)	CIITA;BTK;CD40;...
Antigen processing and presentation	-2.07	9.95e-3	60/78 (76.92%)	KIR3DL1;TNF;HSPA5;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H	Hide ▲

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H	Show ▼