Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMSQ8MD)

Drug Name
Anagrelide Drug Info
Synonyms
Anagrelida; Anagrelidum; BL 416201; Agrylin (TN); Anagrelida [INN-Spanish]; Anagrelide [BAN:INN]; Anagrelide [INN:BAN]; Anagrelidum [INN-Latin]; Xagrid (TN); Anagrelide (INN/BAN); 6,7-Dichlor-1,5-dihydroimidazo(2,1-b)chinazolin-2(3H)-on; 6,7-Dichloro-1,5-dihydroimidazo(2,1-b)quinazolin-2(3H)-one; 6,7-dichloro-1,5-dihydroimidazo[2,1-]quinazolin-2(3H)-one; 6,7-dichloro-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-2-one
Therapeutic ClassAntithrombotic Agents
Cross-matching ID
PubChem CID
135409400
ChEBI ID
CHEMBL760
CAS Number
CAS 68475-42-3
TTD Drug ID
D0D1HW
INTEDE Drug ID
DR0112
ACDINA Drug ID
D00038

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome biogenesis in eukaryotes 2.47 0.00e+0 52/108 (48.15%) NVL;HEATR1;RPP40;...
RNA transport 2.22 0.00e+0 128/186 (68.82%) RPP40;PRMT5;NUP85;...
DNA replication 2.03 0.00e+0 34/36 (94.44%) PRIM1;POLE2;RPA2;...
Ribosome 1.99 0.00e+0 113/158 (71.52%) MRPL15;RPS4Y1;RPL10;...
RNA polymerase 1.96 9.66e-4 23/31 (74.19%) POLR3G;POLR3E;POLR3B;...
Aminoacyl-tRNA biosynthesis 1.88 3.22e-3 15/66 (22.73%) FARSA;DARS2;NARS2;...
Fanconi anemia pathway 1.87 3.45e-3 36/54 (66.67%) RPA2;BRIP1;RAD51;...
Spliceosome 1.82 7.25e-3 101/150 (67.33%) SRSF7;SRSF1;HNRNPA1;...
Nicotine addiction 1.73 1.56e-2 32/40 (80%) GRIA2;SLC17A7;GABRA2;...
Homologous recombination 1.65 2.95e-2 35/41 (85.37%) RPA2;BRIP1;RAD51;...
Complement and coagulation cascades -1.78 8.04e-3 76/85 (89.41%) ITGAX;C2;F5;...
ECM-receptor interaction -1.78 7.86e-3 80/88 (90.91%) THBS1;THBS3;TNXB;...
Fluid shear stress and atherosclerosis -1.79 7.66e-3 123/139 (88.49%) GSTT2;GSTA4;NFE2L2;...
Steroid hormone biosynthesis -1.79 7.45e-3 43/61 (70.49%) CYP3A5;HSD11B2;CYP17A1;...
Type I diabetes mellitus -1.81 5.67e-3 38/43 (88.37%) HLA-DOB;HLA-DRB1;IL1A;...
Arachidonic acid metabolism -1.83 5.36e-3 48/61 (78.69%) CYP2E1;CYP4F2;CBR1;...
Osteoclast differentiation -1.85 4.47e-3 117/127 (92.13%) NFATC1;PPP3CC;SPI1;...
Cholesterol metabolism -1.85 4.66e-3 44/50 (88%) VDAC3;LRP1;APOC3;...
Staphylococcus aureus infection -1.86 3.66e-3 72/95 (75.79%) PTAFR;HLA-DQB1;KRT16;...
Endocytosis -1.86 3.83e-3 198/252 (78.57%) CHMP2B;NEDD4L;RAB5C;...
Other glycan degradation -1.87 3.35e-3 13/18 (72.22%) MAN2B2;MAN2C1;MAN2B1;...
Collecting duct acid secretion -1.88 3.53e-3 22/27 (81.48%) ATP6V1C1;ATP6V1A;ATP6V0C;...
Epithelial cell signaling in Helicobacter pylori infect... -1.88 3.72e-3 62/70 (88.57%) ATP6V1A;ATP6V0C;ATP6V1H;...
Sphingolipid metabolism -1.88 3.94e-3 32/49 (65.31%) CERS4;GLA;UGCG;...
Metabolism of xenobiotics by cytochrome P450 -1.89 4.19e-3 49/77 (63.64%) GSTT2;GSTA4;CYP3A5;...
Autophagy -1.92 2.68e-3 113/169 (66.86%) DAPK2;MAPK1;ATG13;...
Allograft rejection -1.92 1.92e-3 32/38 (84.21%) HLA-DOB;HLA-DRB1;PRF1;...
Toxoplasmosis -1.93 2.06e-3 103/112 (91.96%) AKT1;LY96;HLA-DOB;...
Mitophagy -1.94 2.23e-3 56/68 (82.35%) RRAS2;HIF1A;CITED2;...
Autoimmune thyroid disease -1.94 2.44e-3 46/53 (86.79%) HLA-DOB;HLA-DRB1;PRF1;...
Antigen processing and presentation -1.95 2.68e-3 60/78 (76.92%) HLA-E;HLA-C;CD8A;...
Ferroptosis -2.02 1.49e-3 36/41 (87.8%) GCLM;NCOA4;ACSL1;...
Rheumatoid arthritis -2.03 1.68e-3 78/93 (83.87%) ATP6V0B;HLA-DMB;TNF;...
Graft-versus-host disease -2.11 1.92e-3 32/42 (76.19%) HLA-DOB;HLA-DRB1;IL1A;...
Glycosaminoglycan degradation -2.11 2.23e-3 19/19 (100%) GUSB;GNS;SGSH;...
Mineral absorption -2.22 0.00e+0 48/60 (80%) SLC30A1;ATP2B1;CYBRD1;...
Vibrio cholerae infection -2.29 0.00e+0 44/50 (88%) ARF1;ATP6V0B;PDIA4;...
Phagosome -2.31 0.00e+0 118/152 (77.63%) HGS;HLA-DOB;HLA-DRB1;...
Steroid biosynthesis -2.49 0.00e+0 19/20 (95%) CYP27B1;SOAT1;LIPA;...
Lysosome -2.61 0.00e+0 115/128 (89.84%) GLA;NAGLU;ATP6V0A4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 0.12uM - 10uM 24H
TC-32 CVCL_7141 Homo sapiens 1.11uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Brain
Glioblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-251 MG CVCL_0021 Homo sapiens 0.12uM - 10uM 24H
YH-13 CVCL_1800 Homo sapiens 0.12uM - 10uM 24H
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-474 CVCL_0179 Homo sapiens 0.12uM - 10uM 24H
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
ZR-75-1 CVCL_0588 Homo sapiens 0.12uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GP2d CVCL_1234 Homo sapiens 0.12uM - 10uM 24H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
SNU-407 CVCL_5004 Homo sapiens 0.12uM - 10uM 24H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WA09 (H9) Derived CVCL_9773 (WA09) Homo sapiens 0.12uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 0.12uM - 10uM 24H
HEC-151 CVCL_2927 Homo sapiens 0.12uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 0.12uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 0.12uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 0.12uM - 1.11uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Renal cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RCC10RGB CVCL_1656 Homo sapiens 1.11uM - 10uM 24H
Rhabdoid tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
G-401 CVCL_0270 Homo sapiens 0.12uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 12.5uM 72H
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
JHH-7 CVCL_1322 Homo sapiens 0.12uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
NCI-H1437 CVCL_1472 Homo sapiens 1.11uM - 10uM 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 0.12uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC1588 CVCL_1263 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 0.12uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
NCI-H2110 CVCL_1529 Homo sapiens 0.12uM - 10uM 24H
NCI-H2172 CVCL_1534 Homo sapiens 0.12uM - 10uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H841 CVCL_1595 Homo sapiens 0.12uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Oral cavity
Oral squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BICR 6 CVCL_1086 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVK18 CVCL_1629 Homo sapiens 0.12uM - 10uM 24H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ES-2 CVCL_3509 Homo sapiens 0.12uM 24H
OVTOKO CVCL_3114 Homo sapiens 0.12uM - 10uM 24H
Ovarian cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OAW 28 CVCL_1611 Homo sapiens 0.12uM - 10uM 24H
OC 316 CVCL_1615 Homo sapiens 0.12uM - 10uM 24H
Ovarian endometrioid carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TOV-112D CVCL_3612 Homo sapiens 1.11uM 24H
Ovarian granulosa cell tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV434 CVCL_2010 Homo sapiens 0.12uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 0.12uM - 10uM 24H
LNCaP clone FGC CVCL_1379 Homo sapiens 0.12uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 0.12uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
SK-MEL-3 CVCL_0525 Homo sapiens 0.12uM - 10uM 24H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 0.12uM - 10uM 24H
MKN45 CVCL_0434 Homo sapiens 0.12uM - 10uM 24H
Gastric carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IM95 CVCL_1305 Homo sapiens 0.12uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H