Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMSQRXW)

Drug Name
SQ-32709 Drug Info
Synonyms
farnesyl diphosphate; farnesyl pyrophosphate; (2E,6E)-Farnesyl diphosphate; trans,trans-Farnesyl diphosphate; all-trans-Farnesyl pyrophosphate; (all-E)-Farnesyl diphosphate; (E,E)-Farnesyl pyrophosphate; (2E,6E)-Farnesyl pyrophosphate; trans-Farnesyl pyrophosphate; 2-trans,6-trans-Farnesyl pyrophosphate; farnesyl-PP; (E,E)-Farnesyl diphosphate; 2-trans,6-trans-farnesyl diphosphate; trans-trans-farnesyl diphosphate; UNII-79W6B01D07; CHEBI:17407; trans,trans-Farnesyl pyrophosphate; Sq 32709; 13058-04-3; CHEMBL69330
Cross-matching ID
PubChem CID
445713
ChEBI ID
CHEMBL69330
CAS Number
CAS 372-97-4
TTD Drug ID
D0N5HO
INTEDE Drug ID
DR1927

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome biogenesis in eukaryotes 1.94 2.63e-2 52/108 (48.15%) HEATR1;POP5;IMP3;...
Pentose and glucuronate interconversions 1.89 1.97e-2 17/34 (50%) UGT2B17;UGT2B28;UGP2;...
Ribosome 1.81 3.07e-2 113/158 (71.52%) MRPS16;MRPL16;RPL13A;...
Ascorbate and aldarate metabolism 1.80 3.12e-2 15/30 (50%) UGT2B17;UGT2B28;ALDH3A2;...
Viral protein interaction with cytokine and cytokine re... -1.71 4.40e-2 84/100 (84%) CCL13;CCR2;IL2RB;...
Chagas disease -1.72 4.44e-2 93/102 (91.18%) CFLAR;FOS;PIK3CB;...
Cholinergic synapse -1.72 4.89e-2 99/113 (87.61%) KCNJ12;CACNA1B;CACNA1S;...
Systemic lupus erythematosus -1.76 3.23e-2 45/135 (33.33%) HLA-DOB;HLA-DQB1;C1S;...
Complement and coagulation cascades -1.76 3.63e-2 76/85 (89.41%) CFD;PLAUR;C3;...
Dilated cardiomyopathy -1.76 4.15e-2 86/96 (89.58%) ATP2A3;TPM4;ITGA10;...
Autophagy -1.79 3.30e-2 113/169 (66.86%) PIK3CB;ATG7;LAMP2;...
Longevity regulating pathway -1.81 2.91e-2 90/151 (59.6%) PIK3R3;STK11;RHEB;...
Chemokine signaling pathway -1.82 3.30e-2 163/192 (84.9%) GNG12;ADCY6;PLCG2;...
Estrogen signaling pathway -1.85 2.64e-2 119/137 (86.86%) KRT16;ADCY6;NOS3;...
Hypertrophic cardiomyopathy -1.85 3.96e-2 81/90 (90%) ATP2A3;TPM4;ITGA10;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H