Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMSTH01)

Drug Name
Rocilinostat Drug Info
Synonyms
1316214-52-4; Rocilinostat (ACY-1215); 2-(Diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide; UNII-WKT909C62B; ACY-63; WKT909C62B; 2-(Diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide; AK151416; N-[7-(hydroxyamino)-7-oxoheptyl]-2-(N-phenylanilino)pyrimidine-5-carboxamide; 2-(diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]pyrimidine-5-carboxamide; Ricolinostat [USAN:INN]; AH4; Ricolinostat (USAN/INN); MLS006011181; SCHEMBL574580; GTPL7010
Cross-matching ID
PubChem CID
53340666
ChEBI ID
CHEMBL2364628
CAS Number
CAS 1316214-52-4
TTD Drug ID
D05KED

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Bacterial invasion of epithelial cells 2.18 0.00e+0 59/77 (76.62%) CAV2;CAV1;DNM1;...
Regulation of lipolysis in adipocytes 2.05 0.00e+0 52/55 (94.55%) IRS1;NPY1R;GNAI2;...
Retinol metabolism 2.01 0.00e+0 41/68 (60.29%) ADH1B;ALDH1A2;AOX1;...
Adherens junction 1.98 0.00e+0 63/71 (88.73%) SORBS1;CSNK2B;CDH1;...
Aldosterone-regulated sodium reabsorption 1.94 0.00e+0 34/37 (91.89%) SCNN1A;IRS1;IGF1;...
Pentose and glucuronate interconversions 1.89 8.06e-3 17/34 (50%) AKR1B10;UGT2B15;UGP2;...
Steroid hormone biosynthesis 1.88 6.91e-3 43/61 (70.49%) AKR1C3;SRD5A1;AKR1C2;...
Complement and coagulation cascades 1.81 2.27e-2 76/85 (89.41%) TFPI;SERPINA5;F3;...
Tight junction 1.80 2.15e-2 130/169 (76.92%) MYH10;RAB13;CD1E;...
Retrograde endocannabinoid signaling 1.80 2.18e-2 118/148 (79.73%) GNAI2;GNG11;PRKACA;...
Glycerolipid metabolism 1.78 2.42e-2 44/61 (72.13%) AKR1B10;AGPAT1;MBOAT2;...
Galactose metabolism 1.71 4.13e-2 26/31 (83.87%) AKR1B10;SI;UGP2;...
Terpenoid backbone biosynthesis -1.66 4.86e-2 18/22 (81.82%) PCYOX1;ACAT2;FNTA;...
Herpes simplex virus 1 infection -1.69 3.54e-2 165/498 (33.13%) HLA-G;SP100;EIF2S1;...
Toll-like receptor signaling pathway -1.70 3.60e-2 94/104 (90.38%) CD86;STAT1;CTSK;...
Spliceosome -1.70 4.12e-2 101/150 (67.33%) HNRNPK;THOC1;NCBP1;...
Cytosolic DNA-sensing pathway -1.70 4.17e-2 52/63 (82.54%) DDX58;RIPK1;NFKB1;...
Ferroptosis -1.71 4.86e-2 36/41 (87.8%) ACSL4;ACSL5;TF;...
Antigen processing and presentation -1.79 2.28e-2 60/78 (76.92%) RFX5;IFI30;HSPA2;...
Influenza A -1.83 2.02e-2 156/172 (90.7%) CXCL8;KPNA6;TMPRSS2;...
RNA transport -1.85 2.28e-2 128/186 (68.82%) EIF4A2;FMR1;THOC1;...
One carbon pool by folate -1.86 4.55e-2 15/20 (75%) MTR;FTCD;GART;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HAP1 CVCL_Y019 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 BRD4 (-) 1 CVCL_SF59 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 CDK4 (-) 1 CVCL_SI36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 HDAC5 (-) 1 CVCL_SR11 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 ITGA4 (-) 1 CVCL_ST27 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 MAPK8 (-) 1 CVCL_SW99 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PIK3CA (-) 1 CVCL_TD60 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKACA (-) 1 CVCL_TG70 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKCQ (-) CVCL_TG92 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 RELA (-) 1 CVCL_TI75 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 SRC (-) 1 CVCL_TQ36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 TP53 (-) 1 CVCL_RJ70 Homo sapiens 0.66uM - 3.33uM 24H
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H