Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMSTTV9)

Drug Name
Pemoline Drug Info
Cross-matching ID
PubChem CID
4723
ChEBI ID
CHEMBL7953
CAS Number
CAS 2152-34-3
TTD Drug ID
D0D5GG

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome 1.97 1.47e-2 113/158 (71.52%) MRPS16;MRPL15;MRPS18A;...
Proteasome 1.96 7.34e-3 44/46 (95.65%) PSMB10;PSMD12;PSMA6;...
Cell cycle 1.95 4.89e-3 110/124 (88.71%) CCNB1;CCNE2;PTTG1;...
DNA replication 1.82 3.30e-2 34/36 (94.44%) MCM6;MCM5;PCNA;...
RNA polymerase 1.82 3.08e-2 23/31 (74.19%) POLR2I;POLR1C;POLR3G;...
Ribosome biogenesis in eukaryotes 1.80 2.57e-2 52/108 (48.15%) NXT2;POP1;NOP10;...
PI3K-Akt signaling pathway -1.66 5.00e-2 317/354 (89.55%) IL3RA;RBL2;RELA;...
Protein export -1.67 4.60e-2 17/23 (73.91%) SPCS3;SEC63;OXA1L;...
HIF-1 signaling pathway -1.71 3.71e-2 105/109 (96.33%) SERPINE1;IFNG;PFKL;...
Measles -1.72 3.70e-2 133/139 (95.68%) IL1A;PIK3R1;PIK3R2;...
Rheumatoid arthritis -1.75 3.56e-2 78/93 (83.87%) CXCL5;ATP6V0A4;IL18;...
IL-17 signaling pathway -1.76 3.96e-2 84/94 (89.36%) IFNG;RELA;IL1B;...
NF-kappa B signaling pathway -1.86 1.75e-2 90/104 (86.54%) IKBKB;TNFAIP3;DDX58;...
Ferroptosis -1.90 1.45e-2 36/41 (87.8%) FTH1;GSS;PCBP1;...
Malaria -1.95 1.06e-2 44/50 (88%) ITGB2;KLRB1;IFNG;...
Cytokine-cytokine receptor interaction -1.96 1.27e-2 246/295 (83.39%) CCL8;CCR6;IL2RB;...
Staphylococcus aureus infection -1.98 1.59e-2 72/95 (75.79%) C1QB;DEFA6;FPR3;...
Viral protein interaction with cytokine and cytokine re... -2.01 2.12e-2 84/100 (84%) CCR1;TNFRSF10C;CCL24;...
Primary immunodeficiency -2.03 2.54e-2 33/38 (86.84%) CD40LG;ICOS;DCLRE1C;...
Complement and coagulation cascades -2.19 0.00e+0 76/85 (89.41%) C5AR1;F3;CD55;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H