Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMSUB64)

Drug Name
BAY 57-1293 Drug Info
Synonyms
Pritelivir; 348086-71-5; BAY-57-1293; UNII-07HQ1TJ4JE; AIC316; BAY57-1293; 07HQ1TJ4JE; Pritelivir (BAY 57-1293); N-Methyl-N-(4-methyl-5-sulfamoylthiazol-2-yl)-2-(4-(pyridin-2-yl)phenyl)acetamide; N-methyl-N-(4-methyl-5-sulfamoyl-1,3-thiazol-2-yl)-2-(4-pyridin-2-ylphenyl)acetamide; Pritelivir [INN]; AIC-316; AIC 316; AC1LANY1; PritelivirBAY-57-1293; SCHEMBL1074614; Pritelivir(BAY 57-1293); DTXSID70188344; EX-A247; MolPort-029-887-140; IVZKZONQVYTCKC-UHFFFAOYSA-N; HMS3653B15; BCP08742
Cross-matching ID
PubChem CID
491941
ChEBI ID
CHEMBL4069597
CAS Number
CAS 348086-71-5
TTD Drug ID
D05ZXZ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Metabolism of xenobiotics by cytochrome P450 -1.73 3.57e-2 49/77 (63.64%) HSD11B1;GSTK1;GSTA1;...
TNF signaling pathway -1.73 3.80e-2 103/112 (91.96%) RELA;CX3CL1;MAPK3;...
Basal cell carcinoma -1.74 4.22e-2 41/63 (65.08%) BAK1;FZD3;FZD6;...
Bladder cancer -1.74 4.75e-2 40/41 (97.56%) RASSF1;MAPK3;THBS1;...
Epithelial cell signaling in Helicobacter pylori infect... -1.76 3.55e-2 62/70 (88.57%) GIT1;PTPRZ1;ATP6V0B;...
IL-17 signaling pathway -1.77 4.15e-2 84/94 (89.36%) IL17RC;TRAF6;ELAVL1;...
NF-kappa B signaling pathway -1.78 4.45e-2 90/104 (86.54%) PLCG1;SYK;IKBKB;...
Rheumatoid arthritis -1.85 2.95e-2 78/93 (83.87%) ATP6V0B;ACP5;HLA-DRB1;...
Mineral absorption -1.85 3.93e-2 48/60 (80%) MT1H;ATP2B1;FTL;...
Ribosome -1.93 2.62e-2 113/158 (71.52%) RPS17;MRPL35;RPL9;...
Other glycan degradation -2.02 1.31e-2 13/18 (72.22%) ENGASE;MAN2B2;AGA;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H