Details of the Drug Pharmacogenomic Perturbation Atlas

Darapladib Drug Info

SB 480848; Darapladib (USAN)

Cross-matching ID

PubChem CID

9939609

ChEBI ID

CHEMBL204021

CAS Number

CAS 356057-34-6

TTD Drug ID

D0L5UO

General Information of Drug (ID: DMSWLA3)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Leishmaniasis	2.39	0.00e+0	67/77 (87.01%)	TLR4;HLA-DRA;HLA-DPA1;...
Steroid biosynthesis	2.27	0.00e+0	19/20 (95%)	SQLE;DHCR24;SC5D;...
Phagosome	2.20	0.00e+0	118/152 (77.63%)	TLR4;HLA-DRA;CD36;...
Toxoplasmosis	2.16	0.00e+0	103/112 (91.96%)	GNAI1;TLR4;HLA-DRA;...
Fatty acid biosynthesis	2.01	0.00e+0	16/18 (88.89%)	FASN;ACSL3;ACSL1;...
Pertussis	2.01	0.00e+0	64/76 (84.21%)	GNAI1;TLR4;CALML5;...
Inflammatory bowel disease	1.98	0.00e+0	58/65 (89.23%)	TLR4;HLA-DRA;HLA-DPA1;...
Complement and coagulation cascades	1.98	0.00e+0	76/85 (89.41%)	SERPINB2;CLU;C3;...
Biosynthesis of unsaturated fatty acids	1.97	0.00e+0	21/27 (77.78%)	SCD;FADS1;ELOVL6;...
Hematopoietic cell lineage	1.96	1.14e-3	90/99 (90.91%)	HLA-DRA;CD36;HLA-DPA1;...
Cholesterol metabolism	1.95	1.04e-3	44/50 (88%)	CD36;LDLR;APOA1;...
Rheumatoid arthritis	1.94	9.52e-4	78/93 (83.87%)	TLR4;HLA-DRA;MMP1;...
Asthma	1.90	2.64e-3	25/31 (80.65%)	HLA-DRA;HLA-DPA1;HLA-DPB1;...
Viral protein interaction with cytokine and cytokine re...	1.88	3.26e-3	84/100 (84%)	CXCL2;CCL2;TNFSF10;...
Cell adhesion molecules	1.88	3.81e-3	118/148 (79.73%)	HLA-DRA;CDH2;HLA-DPA1;...
Chagas disease	1.86	4.28e-3	93/102 (91.18%)	GNAI1;TLR4;CCL2;...
Th17 cell differentiation	1.84	4.70e-3	95/107 (88.79%)	HLA-DRA;HLA-DPA1;CD4;...
Herpes simplex virus 1 infection	1.83	6.98e-3	165/498 (33.13%)	HLA-DRA;HLA-DPA1;HLA-DPB1;...
Intestinal immune network for IgA production	1.80	1.02e-2	38/48 (79.17%)	HLA-DRA;HLA-DPA1;HLA-DPB1;...
Fatty acid elongation	1.79	1.03e-2	19/27 (70.37%)	ELOVL6;HACD1;HACD2;...
Staphylococcus aureus infection	1.78	1.03e-2	72/95 (75.79%)	HLA-DRA;HLA-DPA1;KRT19;...
Malaria	1.78	1.09e-2	44/50 (88%)	TLR4;CD36;THBS1;...
Toll-like receptor signaling pathway	1.77	1.14e-2	94/104 (90.38%)	TLR4;SPP1;NFKBIA;...
Graft-versus-host disease	1.76	1.24e-2	32/42 (76.19%)	HLA-DRA;HLA-DPA1;HLA-DPB1;...
Adipocytokine signaling pathway	1.75	1.37e-2	64/69 (92.75%)	CD36;PRKCQ;NFKBIA;...
Nicotinate and nicotinamide metabolism	1.75	1.49e-2	25/35 (71.43%)	SIRT3;NNMT;NT5E;...
Gap junction	1.74	1.65e-2	72/88 (81.82%)	GNAI1;PDGFC;GUCY1A1;...
Renin secretion	1.73	1.79e-2	61/69 (88.41%)	GNAI1;CALML5;GUCY1A1;...
Platelet activation	1.73	1.73e-2	106/124 (85.48%)	GNAI1;GUCY1A1;ITPR3;...
Cytokine-cytokine receptor interaction	1.72	1.78e-2	246/295 (83.39%)	CXCL2;CD4;CCL2;...
Oxidative phosphorylation	-1.89	1.98e-2	93/133 (69.92%)	NDUFA10;COX7A1;NDUFA6;...
Ribosome	-2.37	0.00e+0	113/158 (71.52%)	RPLP1;RPL30;MRPL24;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Ewing sarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
SK-ES-1	CVCL_0627	Homo sapiens	1.11uM - 3.33uM	24H

Brain

Glioma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
GI-1	CVCL_1230	Homo sapiens	1.11uM - 3.33uM	24H

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	24H

MDA-MB-468	CVCL_0419	Homo sapiens	1.11uM - 3.33uM	24H

Breast ductal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
T-47D	CVCL_0553	Homo sapiens	1.11uM - 3.33uM	24H

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 3.33uM	24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H

SNU-407	CVCL_5004	Homo sapiens	1.11uM - 3.33uM	24H

Endometrium

Endometrial adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
HEC-108	CVCL_2926	Homo sapiens	1.11uM - 3.33uM	24H

HEC-1-A	CVCL_0293	Homo sapiens	1.11uM - 3.33uM	24H

HEC-251	CVCL_2928	Homo sapiens	1.11uM - 10uM	24H

HEC-265	CVCL_2929	Homo sapiens	1.11uM - 3.33uM	24H

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
CJM	CVCL_U797	Homo sapiens	1.11uM - 3.33uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H

Liver

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
JHH-5	CVCL_1320	Homo sapiens	1.11uM - 10uM	24H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
NCI-H1573	CVCL_1483	Homo sapiens	1.11uM - 10uM	24H

NCI-H838	CVCL_1594	Homo sapiens	1.11uM - 10uM	24H

Lung squamous cell carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
BEN	CVCL_1081	Homo sapiens	1.11uM - 3.33uM	24H

HCC95	CVCL_1276	Homo sapiens	1.11uM - 10uM	24H

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
NCI-H2110	CVCL_1529	Homo sapiens	1.11uM - 10uM	24H

Muscle

Rhabdomyosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-204	CVCL_0134	Homo sapiens	1.11uM - 3.33uM	24H

Ovary

Ovarian clear cell carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
OVTOKO	CVCL_3114	Homo sapiens	1.11uM - 3.33uM	24H

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
22Rv1	CVCL_1045	Homo sapiens	1.11uM - 3.33uM	24H

PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
A-375	CVCL_0132	Homo sapiens	0.01uM - 3.33uM	24H

IGR-37	CVCL_1303	Homo sapiens	1.11uM - 3.33uM	24H

Mel-HO	CVCL_1402	Homo sapiens	1.11uM - 10uM	24H

SH-4	CVCL_1692	Homo sapiens	1.11uM - 10uM	24H

Urinary bladder

Bladder carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
BC-3C	CVCL_1079	Homo sapiens	1.11uM - 3.33uM	24H

Bladder transitional cell carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
CAL-29	CVCL_1109	Homo sapiens	1.11uM - 3.33uM	24H