Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMSWYF5)

Drug Name
Quinine Drug Info
Synonyms
Aflukin; Chinin; Chinine; Chininum; Conchinin; Conquinine; Quindan; Quinidex; Quinidine; Quinimax; Quinina; Quinineanhydrous; Quinora; Quniacridine; Chinin [German]; Kinder Quinina; QUININE MONO HCL; Quinine Dab; Quinine [BAN]; Quinine anhydrous; Quinine bisulfate; Quinine sulfate; Quinine sulphate; Quinoline alkaloid; LT00645788;Q0028; SB01652; Beta-Quinine; Cin-Quin; Coco-Quinine; IBS-L0034250; Kinder Quinina (TN); Legatrin (TN); Quinine (BAN); Quinine, Anhydrous; Quinine, polymers; Quinine, tannate; Biquinate (*Bisulfate heptathydrate*); Dentojel (*Bisulfate heptathydrate*); Quinamm (*2:1 Sulfate salt*), dihydrate; Quine (*2:1 Sulfate salt*, dihydrate); Quinsan (*2:1 Sulfate salt*), dihydrate; Alpha-(6-Methoxy-4-quinoyl)-5-vinyl-2-quinclidinemethanol; Cinchonan-9-ol, 6'-methoxy-, (8.alpha.,9R)-, sulfate; (+)-Quinidine; (-)-Quinine; (1R)-(6-Methoxyquinolin-4-yl)((1S,4S,5R)-5-vinylquinuclidin-2-yl)methanol; (3A,8A,9r)-6'-methoxycinchonan-9-ol; (5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl)-(6-methoxyquinolin-4-yl)methanol; (8-alpha,9R)-6'-Methoxycinchonan-9-ol; (8.alpha.,9R)-6'-Methoxycinchonan-9-ol; (8S,9R)-6'-Methoxycinchonan-9-ol; (8S,9R)-Quinine; (9R)-6'-methoxy-8alpha-cinchonan-9-ol; (R)-(-)-Quinine, 6-methoxycinchonidine; (R)-(-)-quinine; (R)-(6-Methoxy-quinolin-4-yl)-((2S,5S)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol; (R)-(6-methoxyquinolin-4-yl)((2S,4S,8R)-8-vinylquinuclidin-2-yl)methanol; (R)-[(2S,4R,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol; (R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol; (R)-[(2S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol; (S)-(5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl)-(6-methoxyquinolin-4-yl)methanol; (S)-[(2R,4R,5S)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol; 6'-Methoxycinchonan-9-ol; 6'-Methoxycinchonidine; 6'-Methoxycinchonine; 6-Methoxycinchonine
Therapeutic ClassAntimalarials
Cross-matching ID
PubChem CID
3034034
ChEBI ID
CHEMBL170
CAS Number
CAS 72402-53-0
TTD Drug ID
D03DDR
VARIDT Drug ID
DR00054
INTEDE Drug ID
DR1385
ACDINA Drug ID
D00577

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Amoebiasis 1.84 2.03e-1 99/102 (97.06%) CD14;COL4A2;COL1A2;...
Pertussis 1.75 1.79e-1 64/76 (84.21%) CD14;SFTPA2;RHOA;...
RIG-I-like receptor signaling pathway 1.74 1.23e-1 64/70 (91.43%) CXCL10;CASP10;PIN1;...
Spliceosome 1.72 1.10e-1 101/150 (67.33%) SRSF1;PRPF31;FUS;...
Ether lipid metabolism 1.62 2.15e-1 32/49 (65.31%) LPCAT1;PLA2G2A;PAFAH1B1;...
ECM-receptor interaction 1.56 3.10e-1 80/88 (90.91%) COL4A2;COL1A2;LAMA4;...
Protein digestion and absorption 1.55 2.67e-1 78/103 (75.73%) COL4A2;COL1A2;COL3A1;...
Influenza A 1.55 2.46e-1 156/172 (90.7%) CCL2;CDK6;MAPK1;...
Cell cycle 1.52 2.83e-1 110/124 (88.71%) MYC;MCM5;MCM6;...
Toxoplasmosis 1.51 2.87e-1 103/112 (91.96%) LAMA4;LAMA3;MAPK1;...
Central carbon metabolism in cancer 1.50 2.70e-1 67/70 (95.71%) PGAM1;MYC;MAPK1;...
Graft-versus-host disease 1.49 2.60e-1 32/42 (76.19%) HLA-DPA1;HLA-DQA1;PRF1;...
Focal adhesion 1.48 2.55e-1 180/201 (89.55%) COL4A2;COL1A2;LAMA4;...
Relaxin signaling pathway 1.47 2.71e-1 114/129 (88.37%) COL4A2;COL1A2;COL3A1;...
Epstein-Barr virus infection 1.41 4.24e-1 189/202 (93.56%) MYC;CDK6;AKT1;...
AGE-RAGE signaling pathway in diabetic complications 1.40 4.16e-1 97/100 (97%) CCL2;COL4A2;COL1A2;...
Small cell lung cancer 1.39 4.38e-1 90/92 (97.83%) COL4A2;LAMA4;COL4A1;...
Viral myocarditis 1.39 4.16e-1 53/60 (88.33%) EIF4G1;ITGB2;RAC3;...
Human papillomavirus infection 1.38 4.23e-1 284/331 (85.8%) COL4A2;COL1A2;LAMA4;...
Fc epsilon RI signaling pathway 1.37 4.16e-1 57/68 (83.82%) ALOX5AP;MAPK1;AKT1;...
Autoimmune thyroid disease 1.36 4.40e-1 46/53 (86.79%) HLA-DPA1;HLA-DQA1;PRF1;...
Hepatitis C 1.35 4.52e-1 139/157 (88.54%) MYC;RXRA;CDK6;...
Pathways in cancer 1.31 5.32e-1 474/531 (89.27%) HMOX1;COL4A2;LPAR6;...
Hematopoietic cell lineage 1.30 5.37e-1 90/99 (90.91%) CD14;CD1E;CD1A;...
Cell adhesion molecules 1.30 5.18e-1 118/148 (79.73%) CD99;NRCAM;ITGA6;...
Ribosome biogenesis in eukaryotes 1.30 5.11e-1 52/108 (48.15%) HEATR1;DROSHA;POP5;...
Allograft rejection 1.30 5.03e-1 32/38 (84.21%) HLA-DPA1;HLA-DQA1;PRF1;...
DNA replication 1.29 5.04e-1 34/36 (94.44%) MCM5;MCM6;MCM3;...
Legionellosis 1.28 5.19e-1 51/57 (89.47%) CD14;ITGB2;ARF1;...
Human cytomegalovirus infection 1.28 5.16e-1 201/225 (89.33%) CCL2;MYC;CDK6;...
D-Glutamine and D-glutamate metabolism -1.27 4.76e-1 5/5 (100%) GLUD2;DGLUCY;GLUD1
p53 signaling pathway -1.28 4.64e-1 63/73 (86.3%) TP53;PMAIP1;SESN1;...
Phenylalanine metabolism -1.31 4.50e-1 14/17 (82.35%) GLYAT;HPD;GOT1;...
Colorectal cancer -1.31 4.53e-1 84/86 (97.67%) GADD45A;NRAS;MSH2;...
Drug metabolism -1.31 4.60e-1 78/151 (51.66%) ADH6;CYP2C8;CYP2C9;...
Pyruvate metabolism -1.34 3.97e-1 41/47 (87.23%) PDHB;ACYP2;ALDH7A1;...
Apelin signaling pathway -1.34 4.08e-1 117/137 (85.4%) SMAD2;MEF2D;ADCY3;...
Collecting duct acid secretion -1.35 4.01e-1 22/27 (81.48%) ATP6V1A;ATP6V0A4;ATP6V1G1;...
Basal cell carcinoma -1.35 4.05e-1 41/63 (65.08%) AXIN1;BMP4;BAK1;...
mTOR signaling pathway -1.35 4.20e-1 114/154 (74.03%) GSK3B;IGF1R;DVL3;...
Autophagy -1.36 4.28e-1 113/169 (66.86%) SUPT20H;BCL2L1;IGF1R;...
Valine, leucine and isoleucine degradation -1.36 4.49e-1 42/48 (87.5%) OXCT1;BCKDHA;BCKDHB;...
Epithelial cell signaling in Helicobacter pylori infect... -1.37 4.54e-1 62/70 (88.57%) PAK1;EGFR;JAM2;...
NF-kappa B signaling pathway -1.38 4.77e-1 90/104 (86.54%) PRKCQ;ICAM1;LBP;...
Vibrio cholerae infection -1.41 3.94e-1 44/50 (88%) ATP6V1C1;TJP2;PDIA4;...
Transcriptional misregulation in cancer -1.41 4.01e-1 158/192 (82.29%) GADD45A;JUP;SUPT3H;...
Complement and coagulation cascades -1.42 4.07e-1 76/85 (89.41%) C8B;VWF;CD59;...
Thiamine metabolism -1.45 3.49e-1 12/15 (80%) AK5;TPK1;ACP1;...
Cholesterol metabolism -1.47 3.30e-1 44/50 (88%) LDLR;APOB;APOC1;...
PPAR signaling pathway -1.48 3.49e-1 66/74 (89.19%) ADIPOQ;PDPK1;ACOX1;...
Arginine and proline metabolism -1.50 3.09e-1 39/50 (78%) PRODH2;GAMT;AOC1;...
Purine metabolism -1.50 3.27e-1 102/129 (79.07%) HPRT1;ADCY3;IMPDH2;...
beta-Alanine metabolism -1.53 2.91e-1 25/30 (83.33%) ACOX1;EHHADH;ABAT;...
Regulation of lipolysis in adipocytes -1.53 3.25e-1 52/55 (94.55%) PIK3CB;PTGER3;GNAI2;...
Retinol metabolism -1.55 3.25e-1 41/68 (60.29%) UGT2A3;CYP2C18;UGT2B4;...
Starch and sucrose metabolism -1.69 8.25e-2 25/36 (69.44%) UGP2;HK2;GAA;...
Butanoate metabolism -1.70 9.89e-2 23/28 (82.14%) OXCT1;BDH2;ACSM5;...
Mineral absorption -1.71 1.17e-1 48/60 (80%) ATP2B1;ATP1A1;ATP1A2;...
Proximal tubule bicarbonate reclamation -1.79 7.74e-2 21/23 (91.3%) CA4;ATP1A1;ATP1A2;...
Tyrosine metabolism -1.82 1.12e-1 30/36 (83.33%) HPD;GOT1;ADH1A;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 2.22uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 10uM 6H
MDST8 CVCL_1400 Homo sapiens 10uM 6H
NCI-H508 CVCL_1561 Homo sapiens 10uM 6H
SNU-1040 CVCL_5001 Homo sapiens 10uM 6H
SNU-C4 CVCL_5008 Homo sapiens 10uM 6H
SNU-C5 CVCL_5009 Homo sapiens 10uM 6H
SW480 CVCL_0546 Homo sapiens 10uM 6H
SW620 CVCL_0547 Homo sapiens 10uM 6H
SW948 CVCL_0550 Homo sapiens 10uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 10uM 6H
RKO CVCL_0504 Homo sapiens 10uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 10uM 6H
SNG-M CVCL_1707 Homo sapiens 10uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 10uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 10uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 10uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 10uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 10uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 10uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 10uM 6H
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 10uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 10uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 10uM 6H
OV7 CVCL_1623 Homo sapiens 10uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 10uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMUG-S CVCL_1666 Homo sapiens 10uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 10uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PL-21 CVCL_2161 Homo sapiens 10uM 6H
SKM-1 CVCL_0010 Homo sapiens 10uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 10uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 10uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 10uM 6H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H