Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMSX09A)

Drug Name	PMID28766366-Compound-Scheme8NCGC-00010037 Drug Info
Cross-matching ID	PubChem CID 3232621 ChEBI ID CHEMBL567331 TTD Drug ID D05BVP

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Fanconi anemia pathway	2.07	0.00e+0	36/54 (66.67%)	CENPX;RPA2;REV3L;...
Base excision repair	1.86	1.61e-2	29/33 (87.88%)	PARP2;POLD4;APEX1;...
Ribosome	1.85	1.25e-2	113/158 (71.52%)	RPS4Y1;MRPL12;MRPS12;...
DNA replication	1.80	2.28e-2	34/36 (94.44%)	POLD4;PRIM1;RPA2;...
Gastric acid secretion	-1.65	4.92e-2	63/76 (82.89%)	ATP1B1;CAMK2A;SLC4A2;...
Mineral absorption	-1.66	4.97e-2	48/60 (80%)	MT1E;MT1M;ATP2B2;...
TGF-beta signaling pathway	-1.67	4.90e-2	81/94 (86.17%)	TGIF1;THSD4;CREBBP;...
Renin secretion	-1.68	4.42e-2	61/69 (88.41%)	EDN1;EDN3;NPR1;...
MAPK signaling pathway	-1.69	4.38e-2	272/294 (92.52%)	PPP3R1;EGF;MECOM;...
Signaling pathways regulating pluripotency of stem cell...	-1.69	4.34e-2	110/143 (76.92%)	SMAD5;FZD7;PIK3CB;...
MicroRNAs in cancer	-1.70	4.45e-2	146/310 (47.1%)	RECK;VEGFA;MARCKS;...
Rap1 signaling pathway	-1.71	4.41e-2	184/210 (87.62%)	PRKD2;VEGFA;MAGI2;...
Prostate cancer	-1.73	3.45e-2	93/97 (95.88%)	HSP90B1;CDK2;IKBKB;...
Gastric cancer	-1.74	3.13e-2	122/149 (81.88%)	FZD7;CDK2;CSNK1A1;...
Osteoclast differentiation	-1.76	2.86e-2	117/127 (92.13%)	NFATC1;MITF;FOSL1;...
Lysosome	-1.76	3.12e-2	115/128 (89.84%)	GGA2;ATP6V0A2;CTSL;...
Malaria	-1.77	3.31e-2	44/50 (88%)	IL6;CXCL8;TGFB2;...
Endocrine and other factor-regulated calcium reabsorpti...	-1.79	2.55e-2	49/53 (92.45%)	RAB11A;KL;KLK1;...
Ferroptosis	-1.87	6.36e-3	36/41 (87.8%)	SLC7A11;VDAC2;MAP1LC3B;...
Steroid biosynthesis	-1.93	3.64e-3	19/20 (95%)	HSD17B7;DHCR7;CYP51A1;...
FoxO signaling pathway	-1.93	4.24e-3	118/131 (90.08%)	CDK2;IKBKB;PIK3CB;...
Proximal tubule bicarbonate reclamation	-1.99	0.00e+0	21/23 (91.3%)	GLUD1;PCK2;GLS2;...
Aldosterone-regulated sodium reabsorption	-2.00	0.00e+0	34/37 (91.89%)	PDPK1;NR3C2;NEDD4L;...
Adherens junction	-2.08	0.00e+0	63/71 (88.73%)	RAC1;ACP1;CREBBP;...
Pancreatic secretion	-2.16	0.00e+0	87/102 (85.29%)	ITPR3;ATP2B2;CD38;...
Protein digestion and absorption	-2.22	0.00e+0	78/103 (75.73%)	COL4A5;COL6A1;MEP1B;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	20uM	6H

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H, 24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H

VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H, 24H