Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMSZFTP)

Drug Name
Met-enkephalin Drug Info
Synonyms
MET-enkephalin; H-Tyr-Gly-Gly-Phe-Met-OH; 58569-55-4; Tyr-Gly-Gly-Phe-Met-OH; METENKEFALIN; [Met]enkephalin; [5-Methionine]Enkephalin; TYR-GLY-GLY-PHE-MET; Enkephalin M; UNII-9JEZ9OD3AS; (Met5)-enkephalin; Lupex; 9JEZ9OD3AS; CHEMBL13786; CHEBI:6618; ENKEPHALIN, METHIONINE; Opioid growth factor; [Met5]-ENKEPHALIN; [Met5]Enkephalin acetate salt hydrate; Porcine beta-endorphin 1-5; (2S,5S,14S)-14-Amino-5-benzyl-15-(4-hydroxyphenyl)-2-(2-(methylthio)ethyl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazapentadecan-1-oic
Cross-matching ID
PubChem CID
443363
ChEBI ID
CHEMBL13786
CAS Number
CAS 58569-55-4
TTD Drug ID
D0V5WL

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Amoebiasis 2.04 1.30e-2 99/102 (97.06%) CXCL1;CXCL2;LAMA3;...
Bile secretion 2.00 6.48e-3 68/90 (75.56%) ADCY9;CA2;EPHX1;...
Dilated cardiomyopathy 1.84 1.30e-2 86/96 (89.58%) ADCY9;TPM1;CACNA2D3;...
Glioma 1.82 1.62e-2 67/75 (89.33%) TGFA;PIK3R1;PIK3CB;...
Non-small cell lung cancer 1.81 1.30e-2 70/72 (97.22%) TGFA;MET;PIK3R1;...
Cardiac muscle contraction 1.81 1.08e-2 64/87 (73.56%) TPM1;CACNA2D3;ACTC1;...
Hypertrophic cardiomyopathy 1.80 1.11e-2 81/90 (90%) TPM1;CACNA2D3;TGFB1;...
ECM-receptor interaction 1.79 1.13e-2 80/88 (90.91%) SPP1;LAMA3;HSPG2;...
Parathyroid hormone synthesis, secretion and action 1.78 1.15e-2 98/106 (92.45%) MEF2C;ADCY9;JUND;...
Insulin signaling pathway 1.76 2.07e-2 121/137 (88.32%) PIK3R1;ACACA;PIK3CB;...
Focal adhesion 1.75 1.88e-2 180/201 (89.55%) VEGFA;SPP1;LAMA3;...
Arrhythmogenic right ventricular cardiomyopathy 1.74 1.73e-2 70/77 (90.91%) DSP;CACNA2D3;LMNA;...
Hepatocellular carcinoma 1.73 2.49e-2 135/168 (80.36%) TGFA;MET;HMOX1;...
Proteoglycans in cancer 1.73 2.31e-2 172/205 (83.9%) VEGFA;MMP9;ESR1;...
HIF-1 signaling pathway 1.72 2.94e-2 105/109 (96.33%) VEGFA;HMOX1;PIK3R1;...
Endometrial cancer 1.71 3.00e-2 56/58 (96.55%) PIK3R1;PIK3CB;FOXO3;...
GnRH secretion 1.71 2.82e-2 60/64 (93.75%) SPP1;PIK3R1;PIK3CB;...
Neutrophil extracellular trap formation 1.70 2.88e-2 101/189 (53.44%) HAT1;AZU1;PIK3R1;...
Regulation of actin cytoskeleton 1.68 2.80e-2 185/218 (84.86%) MYH9;FGF9;ACTN1;...
Prostate cancer 1.68 2.66e-2 93/97 (95.88%) TGFA;MMP9;ERG;...
Endocrine and other factor-regulated calcium reabsorpti... 1.68 2.78e-2 49/53 (92.45%) ESR1;ADCY9;VDR;...
Bladder cancer 1.66 3.59e-2 40/41 (97.56%) VEGFA;MMP9;CXCL8;...
Transcriptional misregulation in cancer 1.65 4.00e-2 158/192 (82.29%) MEF2C;MMP9;IGFBP3;...
Insulin secretion 1.65 4.05e-2 75/86 (87.21%) ADCY9;TRPM4;GNA11;...
Mucin type O-glycan biosynthesis 1.64 4.30e-2 20/36 (55.56%) GALNT1;GALNT3;GALNT7;...
ErbB signaling pathway 1.64 4.24e-2 79/85 (92.94%) TGFA;PIK3R1;PIK3CB;...
IL-17 signaling pathway 1.63 4.13e-2 84/94 (89.36%) CXCL1;CXCL2;MMP9;...
Melanoma 1.63 3.98e-2 68/72 (94.44%) FGF9;MET;PIK3R1;...
Chronic myeloid leukemia 1.62 4.24e-2 72/76 (94.74%) PIK3R1;PIK3CB;TGFBR2;...
Other types of O-glycan biosynthesis 1.62 4.27e-2 29/47 (61.7%) ST6GAL1;GALNT1;GALNT3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.02uM - 4uM 24H