Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMT0O7H)

Drug Name
MK-886 Drug Info
Synonyms
MK-886; 118414-82-7; MK 886; MK886; 3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl)-2,2-dimethylpropanoic acid; UNII-080626SQ8C; QAOAOVKBIIKRNL-UHFFFAOYSA-N; L-663,536; CHEMBL29097; CHEBI:75390; L 663536; MK-886 (L-663,536); 080626SQ8C; 3-[3-tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-propan-2-ylindol-2-yl]-2,2-dimethylpropanoic acid; 1H-Indole-2-propanoic acid, 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-Alpha,Alpha-dimethyl-5-(1-methylethyl)- [CAS]; L-663536; SMR000466278
Cross-matching ID
PubChem CID
3651377
ChEBI ID
CHEMBL29097
CAS Number
CAS 118414-82-7
TTD Drug ID
D0K2ER

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Pathogenic Escherichia coli infection 1.87 3.49e-2 152/197 (77.16%) TUBB2A;PAK1;IL6;...
Cell cycle -1.73 4.46e-2 110/124 (88.71%) PRKDC;CDK1;RB1;...
mRNA surveillance pathway -1.75 3.34e-2 71/98 (72.45%) GLE1;DAZAP1;RNGTT;...
Staphylococcus aureus infection -1.80 3.13e-2 72/95 (75.79%) KRT18;FCGR2C;CFH;...
Spliceosome -1.88 1.39e-2 101/150 (67.33%) PRPF18;SRSF7;DDX46;...
DNA replication -2.27 0.00e+0 34/36 (94.44%) POLD3;POLD2;RFC1;...
Antigen processing and presentation -2.35 0.00e+0 60/78 (76.92%) HSP90AB1;KLRC3;HSPA4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H