Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMT0QK8)

• Drug Name: TNP-470 Drug Info
• Synonyms: tnp 470; CCRIS 8049; C19H28ClNO6; O-chloroacetylcarbamoyl fumagillol; MSHZHSPISPJWHW-HUTWWKRSSA-N; Carbamic acid, (chloroacetyl)-, 5-methoxy-4-(2-methyl-3-(3-methyl-2-butenyl)oxiranyl)-1-oxaspiro(2.5)oct-6-yl ester, (3R-(3alpha,4alpha(2R*,3R*),5beta,6beta))-
• Cross-matching ID:
  PubChem CID: 369976
  ChEBI ID: CHEMBL90748
  CAS Number: CAS 129298-91-5
  TTD Drug ID: D09OAQ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Complement and coagulation cascades	2.37	0.00e+0	76/85 (89.41%)	FGG;C5AR1;CFB;...
Ferroptosis	2.16	0.00e+0	36/41 (87.8%)	HMOX1;FTH1;SLC7A11;...
Protein processing in endoplasmic reticulum	2.14	0.00e+0	127/171 (74.27%)	DNAJB1;HSPA6;RRBP1;...
Glutathione metabolism	2.10	0.00e+0	43/57 (75.44%)	GSTA1;G6PD;GSTP1;...
Staphylococcus aureus infection	2.03	0.00e+0	72/95 (75.79%)	FGG;C5AR1;CFB;...
Protein digestion and absorption	1.89	1.65e-2	78/103 (75.73%)	SLC7A7;FXYD2;COL5A1;...
Lysosome	1.85	1.55e-2	115/128 (89.84%)	MCOLN1;CTSZ;GLA;...
Metabolism of xenobiotics by cytochrome P450	1.83	1.48e-2	49/77 (63.64%)	AKR1C1;GSTA1;GSTP1;...
Amoebiasis	1.80	1.87e-2	99/102 (97.06%)	GNAS;TLR4;TGFB1;...
Pentose phosphate pathway	1.79	1.98e-2	25/30 (83.33%)	G6PD;GPI;TALDO1;...
Neutrophil extracellular trap formation	1.77	2.79e-2	101/189 (53.44%)	TLR4;FGG;C5AR1;...
Drug metabolism	1.75	3.79e-2	78/151 (51.66%)	GSTA1;GSTP1;DPYD;...
Antigen processing and presentation	1.72	4.34e-2	60/78 (76.92%)	HSPA6;IFI30;HSPA8;...
Porphyrin and chlorophyll metabolism	1.72	4.24e-2	23/43 (53.49%)	HMOX1;UGT2B28;UGT2B4;...
Steroid hormone biosynthesis	1.69	4.75e-2	43/61 (70.49%)	AKR1C3;AKR1C2;AKR1C1;...
Thyroid hormone synthesis	1.69	4.70e-2	66/75 (88%)	GNAS;GPX2;FXYD2;...
Legionellosis	1.68	4.71e-2	51/57 (89.47%)	HSPA6;TLR4;CD14;...
Tuberculosis	1.67	4.89e-2	159/180 (88.33%)	TLR4;LBP;TGFB1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Fibroblast

Nasopharyngeal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
FIBRNPC	CVCL_UK07	Homo sapiens	10uM	6H, 24H	Hide ▲